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CD32B Protein, Human, Recombinant (His)

Catalog No. TMPJ-00192
Synonyms: FCG2, IgG Fc Receptor II-b, CDw32, Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b, Low Affinity Immunoglobulin γ Fc Region Receptor II-b, FCGR2B, Fc-γ-RIIb, FcRII-b, Fc-Gamma RII-b, Fc-Gamma-RIIb, Fc-γ RII-b, IGFR2, CD32

FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
CD32B Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 97.00
50 μg 5 days $ 272.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.
Species Human
Expression System HEK293 Cells
Tag C-6xHis
Accession Number P31994
Synonyms FCG2, IgG Fc Receptor II-b, CDw32, Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b, Low Affinity Immunoglobulin γ Fc Region Receptor II-b, FCGR2B, Fc-γ-RIIb, FcRII-b, Fc-Gamma RII-b, Fc-Gamma-RIIb, Fc-γ RII-b, IGFR2, CD32
Amino Acid Thr43-Pro217
Construction Thr43-Pro217
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 22-30 KDa, reducing conditions
Endotoxin < 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing 20 mM PB, 150 mM NaCl, pH 7.2.
Reconstitution Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Stability & Storage

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted proteinsolutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.

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Keywords

CD32B Protein, Human, Recombinant (His) IGFR 2 FCG-2 FCG2 FCG 2 IgG Fc Receptor II-b CDw32 Low Affinity Immunoglobulin Gamma Fc Region Receptor II-b IGFR-2 Low Affinity Immunoglobulin γ Fc Region Receptor II-b FCGR2B Fc-γ-RIIb CD-32 FcRII-b CD 32 Fc-Gamma RII-b Fc-Gamma-RIIb Fc-γ RII-b IGFR2 CD32 recombinant recombinant-proteins proteins protein

 

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