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Thiorphan

Name: Thiorphan
Brand: TargetMol
SKU: T7693
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7693Cas No. 76721-89-6

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

Thiorphan

🥰Excellent

Purity: 99.33%

Catalog No. T7693Cas No. 76721-89-6

Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).

Pack Size	Price	Availability
2 mg	$30	In Stock
5 mg	$48	In Stock
10 mg	$85	In Stock
25 mg	$179	In Stock
50 mg	$268	In Stock
100 mg	$398	In Stock
500 mg	$916	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.33%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Thiorphan is an neprilysin inhibitor (NEP; IC50 : 0.007 μM).
Targets&IC50	NEP:0.007 µM
In vivo	Thiorphan reduces increases in gastric acid output induced by pentagastrin by 64% in rats when administered intracerebroventricularly at a dose of 50 μg, but not when administered intravenously at doses of 1.7 and 17 mg/kg[1]

Chemical Properties

Molecular Weight	253.32
Formula	C₁₂H₁₅NO₃S
Cas No.	76721-89-6
Smiles	OC(=O)CNC(=O)C(CS)Cc1ccccc1
Relative Density.	1.246 g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (217.12 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9476 mL	19.7379 mL	39.4758 mL	197.3788 mL
5 mM	0.7895 mL	3.9476 mL	7.8952 mL	39.4758 mL
10 mM	0.3948 mL	1.9738 mL	3.9476 mL	19.7379 mL
20 mM	0.1974 mL	0.9869 mL	1.9738 mL	9.8689 mL
50 mM	0.0790 mL	0.3948 mL	0.7895 mL	3.9476 mL
100 mM	0.0395 mL	0.1974 mL	0.3948 mL	1.9738 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc