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Cilastatin sodium

Name: Cilastatin sodium
Brand: TargetMol
SKU: T2583L
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: MK-0791 sodium, MK0791 sodium, Cilastatinum) Copy Product Info

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Synonyms: MK-0791 sodium, MK0791 sodium, Cilastatinum

Catalog No. T2583L Copy Product Info

Purity: 99.08%

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Cilastatin (MK-0791) is a potent, reversible, competitive inhibitor of renal dehydropeptidase I (DHP-I), exhibiting an IC₅₀ of 0.1 μM. By inhibiting DHP-I in the kidney, Cilastatin prevents the enzymatic degradation of β-lactam antibiotics, thereby enhancing their stability and therapeutic efficacy. In addition, Cilastatin demonstrates inhibitory activity against the bacterial metallo-β-lactamase enzyme CphA, with an IC₅₀ of 178 μM. Clinically and experimentally, Cilastatin is widely used as an antibacterial adjunct to improve antibiotic performance and reduce renal metabolism of co-administered β-lactam drugs.

Cas No. 81129-83-1

Pack Size	Price	USA Stock	Global Stock
5 mg	$31	-	In Stock
10 mg	$49	-	In Stock
25 mg	$74	-	In Stock
50 mg	$89	-	In Stock
100 mg	$139	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.08%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Cilastatin (MK-0791) is a potent, reversible, competitive inhibitor of renal dehydropeptidase I (DHP-I), exhibiting an IC₅₀ of 0.1 μM. By inhibiting DHP-I in the kidney, Cilastatin prevents the enzymatic degradation of β-lactam antibiotics, thereby enhancing their stability and therapeutic efficacy. In addition, Cilastatin demonstrates inhibitory activity against the bacterial metallo-β-lactamase enzyme CphA, with an IC₅₀ of 178 μM. Clinically and experimentally, Cilastatin is widely used as an antibacterial adjunct to improve antibiotic performance and reduce renal metabolism of co-administered β-lactam drugs.
Targets & IC50	Metallob-lactamase enzyme CphA (bacterial):178 μM (IC50), Renal dehydropeptidase I:0.1 μM (IC50)
Synonyms	MK-0791 sodium, MK0791 sodium, Cilastatinum

Chemical Properties

Molecular Weight	380.44
Formula	C₁₆H₂₅N₂NaO₅S
Cas No.	81129-83-1
Smiles	[O-]C([C@@H](N)CSCCCC/C=C(C(O)=O)\NC([C@@H]1C(C)(C1)C)=O)=O.[Na+]
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from direct sunlight,Store under nitrogen, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80.00 mg/mL (210.28 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.6285 mL	13.1427 mL	26.2854 mL	131.4268 mL
5 mM	0.5257 mL	2.6285 mL	5.2571 mL	26.2854 mL
10 mM	0.2629 mL	1.3143 mL	2.6285 mL	13.1427 mL
20 mM	0.1314 mL	0.6571 mL	1.3143 mL	6.5713 mL
50 mM	0.0526 mL	0.2629 mL	0.5257 mL	2.6285 mL
100 mM	0.0263 mL	0.1314 mL	0.2629 mL	1.3143 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc