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EGFR-IN-16

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Catalog No. T8525Cas No. 133550-22-8
Alias AG473

EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.

EGFR-IN-16

EGFR-IN-16

😃Good
Catalog No. T8525Alias AG473Cas No. 133550-22-8
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$1226-8 weeks6-8 weeks
10 mg$1956-8 weeks6-8 weeks
25 mg$3706-8 weeks6-8 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
EGFR-IN-16 (AG473) is an inhibitor of EGFR in human A431 cells.
Targets&IC50
HER2:4.74 (pIC50), EGFR:4.85 (pIC50)
In vivo
Expressed the EGFR-IN-16 lipoprotein from Neisseria meningitides, flagellin FlaB from Vibrio vulnificus and heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) in Escherichia coli as single proteins and fusion proteins with VP2 protein of infectious bursal disease virus (IBDV).Both cellular and humoral adjuvanticities of the three TLR ligands were compared by immunization of mice in two different ways.Among the three co-administered TLR ligands, recombinant EGFR-IN-16 lipoprotein exhibited the highest cellular and humoral adjuvanticities, including promotion of IL-4, IL-12, IFN-γ and IBDV VP2-specific antibody production.Among the three genetically fused TLR ligands, fusion with EGFR-IN-16 D1 domain exhibited the highest cellular and humoral adjuvanticities.
SynonymsAG473
Chemical Properties
Molecular Weight265.26
FormulaC16H11NO3
Cas No.133550-22-8
SmilesC(=C(/C(=O)C1=CC=CC=C1)\C#N)\C2=CC(O)=C(O)C=C2
Relative Density.1.350 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitHER1FGFRErbB-1Epidermal growth factor receptorEGFR-IN-16EGFRIN16EGFR IN 16EGFRAG-473AG 473
Related Tags: buy EGFR-IN-16 | purchase EGFR-IN-16 | EGFR-IN-16 cost | order EGFR-IN-16 | EGFR-IN-16 chemical structure | EGFR-IN-16 in vivo | EGFR-IN-16 formula | EGFR-IN-16 molecular weight
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