Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Myosin

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility.

(-)-Blebbistatin
T6038856925-71-8
(-)-Blebbistatin ((S)-(-)-Blebbistatin) is an S enantiomer of blebbistatin. It is a potent and selective myosin II inhibitor with IC50 ranging from 0.5 to 5 μM.
  • $35
In Stock
Size
QTY
TargetMol | Citations Cited
JB062
T679522417988-00-0
JB062 is a chemical compound acting as a nonmuscle myosin inhibitor, exhibiting IC50 values of 1.6, 5.4, and >100 μM against skeletal muscle myosin, cardiac muscle myosin, and smooth muscle myosin II, respectively. It selectively exhibits cytotoxicity towards human cancer cells without affecting normal cells. The compound is applicable in research fields concerning muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
  • $195
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ATM-3507
T10395L1861449-70-8In house
ATM-3507 is a protomyosin inhibitor with anticancer activity that inhibits human melanoma and can be used to study ovarian cancer.
  • $117
In Stock
Size
QTY
Blebbistatin
T21550674289-55-5
Blebbistatin ((±)-Blebbistatin) is a non-muscle myosin II (NMII)-selective and non-muscle myosin heavy chain 9 (MYH9)-specific inhibitor that promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, while preserving the integrity of cell junctions and barrier function.
  • $30
In Stock
Size
QTY
Phenamacril
T2421439491-78-6
Phenamacril (JS39919) is acyanoacrylate fungicide, has powerful inhibition against Fusarium species, especially to Fusarium graminearum. Phenamacril is a specific Fusarium myosin I inhibitor.
  • $148
In Stock
Size
QTY
TargetMol | Inhibitor Sale
JB002
T7202330408-07-2
JB002, a myosin II inhibitor, exhibits potent activity with an IC50 of ≤10 μM. It holds potential for research applications in muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy.
  • $70
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ML-7 hydrochloride
T3050110448-33-4
ML-7 hydrochloride (ML-7 HCl) is a cell-permeable, reversible, effective, ATP-competitive, and specific inhibitor of myosin light chain kinase (Ki: 300 nM); also inhibits smooth-muscle myosin light chain kinase, PKA, and PKC.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Myosin V-IN-1
T720601259177-59-7In house
Myosin V-IN-1 is a potent and selective inhibitor of Myosin V with a Ki value of 6 μM.Myosin V-IN-1 inhibits actin V and slows down actin-activated myosin V ATPase by selectively inhibiting the release of ADP from the actinoglobulin complex.
  • $330
In Stock
Size
QTY
W-7 hydrochloride
T2079261714-27-0
W-7 hydrochloride (W-7 HCl), a calmodulin antagonist, inhibits Ca2+-calmodulin-dependent myosin light chain kinase and phosphodiesterase, W-7 hydrochloride induces apoptosis and has antitumor activity.
  • $30
In Stock
Size
QTY
Pentachloropseudilin
T2461269640-38-6
Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
  • $1,520
6-8 weeks
Size
QTY
Danicamtiv
T150501970972-74-7
Danicamtiv (MYK-491) is an inotropic agent and it also is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency.
  • $138
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Mavacamten
T71341642288-47-8
Mavacamten (MYK-461) is an orally bioavailable inhibitor of cardiac myosin ATPase,( IC50s of 490, 711 nM for bovine cardiac and human cardiac, respectively)
  • $40
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Omecamtiv mecarbil
T2006873697-71-3
Omecamtiv mecarbil (CK-1827452) has been used in trials studying the treatment and basic science of Heart Failure, Echocardiogram, Pharmacokinetics, Chronic Heart Failure, and History of Chronic Heart Failure, among others.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
para-Nitroblebbistatin
T123601621326-32-6In house
para-Nitroblebbistatin is a non-cytotoxic, non-fluorescent, photostable, and specific inhibitor of myosin II. para-Nitroblebbistatin can be used to study the specific roles of myosin II in physiology, development, and cell biology.
  • $89
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ML-9
T16104105637-50-1
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction molecule 1 (STIM1) activity. ML-9 causes autophagy by stimulating autophagosome formation and inhibiting their degradation.
  • $34
In Stock
Size
QTY
TargetMol | Citations Cited
JB061
T67951
JB061 is a nonmuscle myosin inhibitor, demonstrating selective inhibitory activity with IC50 values of 4.4 μM (Cardiac muscle myosin), 9.1 μM (Skeletal muscle myosin), and >100 μM (Smooth muscle myosin II). It exhibits limited efficacy in reducing ATPase activity, with an IC50 exceeding 200 μM. Furthermore, JB061 displays cytotoxic effects on COS-7 cells, evidenced by an IC50 value of 39 μM.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Sale
HA-100
T764884468-24-6
HA-100 is an inhibitor of protein kinase
  • $57
In Stock
Size
QTY
TargetMol | Citations Cited
MS-444
T16145150045-18-4In house
MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
  • $624
In Stock
Size
QTY
BTS
T71441576-37-0
BTS (N-Tosylbenzylamine) is a potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 : 5 μM) .
  • $29
In Stock
Size
QTY
TargetMol | Inhibitor Sale
16-38-Thymosin β4 (cattle) (TFA)
T80088
Thymosin β4 (cattle) TFA is a high-affinity activator of MLCK that operates independently of Ca2+ [1].
  • Inquiry Price
Size
QTY