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Solifenacin succinate

Name: Solifenacin succinate
Brand: TargetMol
SKU: T0111
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0111Cas No. 242478-38-2

Alias YM905

Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

Solifenacin succinate

🥰Excellent

Purity: 99.98%

Catalog No. T0111Alias YM905Cas No. 242478-38-2

Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

Pack Size	Price	Availability
50 mg	$30	In Stock
100 mg	$53	In Stock
500 mg	$118	In Stock
1 g	$173	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.98%

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Product Introduction

Bioactivity

Description	Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.
In vivo	Solifenacin succinate is a novel muscarinic antagonist indicated for the treatment of overactive bladder syndrome. When co-administered with oxybutynin, Solifenacin effectively inhibits the mobilization of intracellular calcium mediated by muscarinic M3 receptors in isolated bladder smooth muscle cells of guinea pigs and submandibular gland cells of mice.
Synonyms	YM905

Chemical Properties

Molecular Weight	480.56
Formula	C₂₃H₂₆N₂O₂·C₄H₆O₄
Cas No.	242478-38-2
Smiles	O(C(=O)N1[C@H](c2c(CC1)cccc2)c1ccccc1)[C@@H]1C2CCN(C1)CC2.O=C(O)CCC(=O)O
Relative Density.	1.24g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (52.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0809 mL	10.4045 mL	20.8091 mL	104.0453 mL
5 mM	0.4162 mL	2.0809 mL	4.1618 mL	20.8091 mL
10 mM	0.2081 mL	1.0405 mL	2.0809 mL	10.4045 mL
20 mM	0.1040 mL	0.5202 mL	1.0405 mL	5.2023 mL
50 mM	0.0416 mL	0.2081 mL	0.4162 mL	2.0809 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc