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CBL 0100 free base
🥰Excellent
Catalog No. T71263Cas No. 1197996-83-0
Alias Curaxin 100, CBL0100 free base, CBL 0100 free base, 6-[2-(Diethylamino)ethyl]-10,11-dihydro-1H-dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione (ACI), 1H-Dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione, 6-[2-(diethylamino)ethyl]-10,11-dihydro- (ACI)
CBL 0100 free base is an HIV-1 transcription inhibitor that blocks HIV-1 replication and reactivation in vitro and in ex vivo models. It targets the chromatin-associated transcription (FACT) complex, reducing the occupancy of RNA Polymerase II and FACT in the HIV-1 promoter region, and can be used as a latency-reversing agent (LRA) in cART therapy.
CBL 0100 free base
🥰Excellent
Purity: 98.86%
Catalog No. T71263Alias Curaxin 100, CBL0100 free base, CBL 0100 free base, 6-[2-(Diethylamino)ethyl]-10,11-dihydro-1H-dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione (ACI), 1H-Dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione, 6-[2-(diethylamino)ethyl]-10,11-dihydro- (ACI)Cas No. 1197996-83-0
CBL 0100 free base is an HIV-1 transcription inhibitor that blocks HIV-1 replication and reactivation in vitro and in ex vivo models. It targets the chromatin-associated transcription (FACT) complex, reducing the occupancy of RNA Polymerase II and FACT in the HIV-1 promoter region, and can be used as a latency-reversing agent (LRA) in cART therapy.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $333 | - | In Stock | |
| 5 mg | $790 | - | In Stock | |
| 10 mg | $1,120 | - | In Stock | |
| 25 mg | $1,670 | - | In Stock | |
| 50 mg | $2,230 | - | In Stock | |
| 100 mg | $2,950 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.86%
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Product Introduction
Bioactivity
Chemical Properties
| Description | CBL 0100 free base is an HIV-1 transcription inhibitor that blocks HIV-1 replication and reactivation in vitro and in ex vivo models. It targets the chromatin-associated transcription (FACT) complex, reducing the occupancy of RNA Polymerase II and FACT in the HIV-1 promoter region, and can be used as a latency-reversing agent (LRA) in cART therapy. |
| In vitro | Treatment of J-LAT A1 and A2 cells with CBL 0100 free base (0.1 μM) resulted in a decrease in both the GFP+ cell population and the GFP mean fluorescence intensity (MFI) in J-LAT A1 and A2 cells without any cytotoxicity.[1] |
| Synonyms | Curaxin 100, CBL0100 free base, CBL 0100 free base, 6-[2-(Diethylamino)ethyl]-10,11-dihydro-1H-dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione (ACI), 1H-Dicyclopenta[c,g]carbazole-3,9(2H,6H)-dione, 6-[2-(diethylamino)ethyl]-10,11-dihydro- (ACI) |
| Molecular Weight | 374.48 |
| Formula | C24H26N2O2 |
| Cas No. | 1197996-83-0 |
| Smiles | O=C1C2=CC=C3C(C=4C(=CC=C5C(=O)CCC54)N3CCN(CC)CC)=C2CC1 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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