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Rocuronium bromide

🥰Excellent
Catalog No. T0156Cas No. 119302-91-9
Alias ORG 9426 (Bromide), ORG 9426

Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.

Rocuronium bromide
Other Forms of Rocuronium bromide:
RocuroniumT12748143558-00-3
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Rocuronium bromide

🥰Excellent
Purity: 99.77%
Catalog No. T0156Alias ORG 9426 (Bromide), ORG 9426Cas No. 119302-91-9
Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
10 mg$45In StockIn Stock
50 mg$61In StockIn Stock
100 mg$81In StockIn Stock
200 mg$105In StockIn Stock
500 mg$142In StockIn Stock
1 mL x 10 mM (in DMSO)$50In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.77%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
In vitro
Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner [1]. It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects [2]. The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes [3].
SynonymsORG 9426 (Bromide), ORG 9426
Chemical Properties
Molecular Weight609.68
FormulaC32H53BrN2O4
Cas No.119302-91-9
Smiles[Br-].[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)[C@H](C[C@]12C)N1CCOCC1)[N+]1(CC=C)CCCC1
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 113 mg/mL (185.34 mM), Sonication is recommended.
H2O: 112 mg/mL (183.7 mM), Sonication is recommended.
Ethanol: 113 mg/mL (185.34 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.6402 mL8.2010 mL16.4020 mL82.0102 mL
5 mM0.3280 mL1.6402 mL3.2804 mL16.4020 mL
10 mM0.1640 mL0.8201 mL1.6402 mL8.2010 mL
20 mM0.0820 mL0.4101 mL0.8201 mL4.1005 mL
50 mM0.0328 mL0.1640 mL0.3280 mL1.6402 mL
100 mM0.0164 mL0.0820 mL0.1640 mL0.8201 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Keywords

Rocuronium BromideRocuronium bromideRocuroniumORG-9426ORG9426mAChRInhibitorinhibit
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