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Rocuronium bromide

Name: Rocuronium bromide
Brand: TargetMol
SKU: T0156
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0156Cas No. 119302-91-9

Alias ORG 9426 (Bromide), ORG 9426

Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.

Rocuronium bromide

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Purity: 99.77%

Catalog No. T0156Alias ORG 9426 (Bromide), ORG 9426Cas No. 119302-91-9

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$45	In Stock	In Stock
50 mg	$61	In Stock	In Stock
100 mg	$81	In Stock	In Stock
200 mg	$105	In Stock	In Stock
500 mg	$142	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.77%

Color:White to Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rocuronium bromide (ORG 9426) is a muscle relaxant or aminosteroid non-depolarizing neuromuscular blocker. During surgery or mechanical ventilation, it is used to facilitate endotracheal intubation and to provide skeletal muscle relaxation.
In vitro	Rocuronium effectively reduces indirectly elicited twitch tensions in both normal diaphragms (IC50: 9.84 μM) and those pretreated, showing a significant decrease (P < .01, n = 6) in a concentration-dependent manner [1]. It exhibits a similar ED95 for both children and adults, with a duration of action comparable to vecuronium but is shorter in children. Conventional doses of cholinesterase inhibitors can readily reverse its effects [2]. The onset time for maximum block is 1.7 (32) minutes, with the duration until 25% recovery of twitch height at 53 (19) minutes, and recovery from 25% to 75% of twitch height taking 20 (37) minutes [3].
Synonyms	ORG 9426 (Bromide), ORG 9426

Chemical Properties

Molecular Weight	609.68
Formula	C₃₂H₅₃BrN₂O₄
Cas No.	119302-91-9
Smiles	[Br-].[H][C@@]12C[C@@H]([C@H](OC(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC[C@@]2([H])C[C@H](O)[C@H](C[C@]12C)N1CCOCC1)[N+]1(CC=C)CCCC1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 113 mg/mL (185.34 mM), Sonication is recommended.

H2O: 112 mg/mL (183.7 mM), Sonication is recommended.

Ethanol: 113 mg/mL (185.34 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (5.41 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.6402 mL	8.2010 mL	16.4020 mL	82.0102 mL
5 mM	0.3280 mL	1.6402 mL	3.2804 mL	16.4020 mL
10 mM	0.1640 mL	0.8201 mL	1.6402 mL	8.2010 mL
20 mM	0.0820 mL	0.4101 mL	0.8201 mL	4.1005 mL
50 mM	0.0328 mL	0.1640 mL	0.3280 mL	1.6402 mL
100 mM	0.0164 mL	0.0820 mL	0.1640 mL	0.8201 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc