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Anti-P4HB Antibody-HRP (1Y42)
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Catalog No. TMAY-01235H
Alias Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59
Anti-P4HB Antibody-HRP (1Y42) is a HRP-conjugated Mouse antibody targeting P4HB. Anti-P4HB Antibody-HRP (1Y42) can be used in ELISA.
Anti-P4HB Antibody-HRP (1Y42)
Anti-P4HB Antibody-HRP (1Y42)
😃Good
Catalog No. TMAY-01235HAlias Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59
Anti-P4HB Antibody-HRP (1Y42) is a HRP-conjugated Mouse antibody targeting P4HB. Anti-P4HB Antibody-HRP (1Y42) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μg | $292 | 7-10 days |
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Chemical Properties
| Description | Anti-P4HB Antibody-HRP (1Y42) is a HRP-conjugated Mouse antibody targeting P4HB. Anti-P4HB Antibody-HRP (1Y42) can be used in ELISA. |
| Alias | Thbp, prolyl 4-hydroxylase, β polypeptide, prolyl 4-hydroxylase, beta polypeptide, Pdia1, PDI, ERp59 |
| Ig Type | Monoclonal Mouse IgG1 |
| Clone | 1Y42 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 0.1-1 μg/ml |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human P4HB / ERBA2L (rh P4HB; TMPY-01012; NP_000909.2; Met 1-Lys 505). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with horseradish-peroxidase (HRP). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Protein disulfide-isomerase, also known as Cellular thyroid hormone-binding protein, Prolyl 4-hydroxylase subunit beta, p55 and P4HB, is a peripheral membrane protein that belongs to the protein disulfide isomerase family. P4HB is highly abundant. In some cell types, it seems to be also secreted or associated with the plasma membrane, where it undergoes constant shedding and replacement from intracellular sources. P4HB localizes near CD4-enriched regions on lymphoid cell surfaces. It is identified by mass spectrometry in melanosome fractions from stage I to stage IV. P4HB reduces and may activate fusogenic properties of HIV-1 gp12 surface protein, thereby enabling HIV-1 entry into the cell. P4HB catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, it seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. P4HB may therefore cause structural modifications of exofacial proteins. Inside the cell, it seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, P4HB functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, it facilitates aggregation (anti-chaperone activity). P4HB may be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. It also acts as a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. |
| Conjucates | HRP |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Human P4HB protein (TMPY-01012) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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