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HG-10-102-01

🥰Excellent
Catalog No. T7196Cas No. 1351758-81-0

HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).

HG-10-102-01

HG-10-102-01

🥰Excellent
Purity: 99.59%
Catalog No. T7196Cas No. 1351758-81-0
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
2 mg$32In StockIn Stock
5 mg$53In StockIn Stock
10 mg$86In StockIn Stock
25 mg$173In StockIn Stock
50 mg$278In StockIn Stock
100 mg$401In StockIn Stock
200 mg$569-In Stock
1 mL x 10 mM (in DMSO)$59In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.59%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).
In vivo
HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells.?When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.
Chemical Properties
Molecular Weight377.83
FormulaC17H20ClN5O3
Cas No.1351758-81-0
SmilesCNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
Relative Density.1.381 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 50 mg/mL (132.33 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.29 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6467 mL13.2335 mL26.4669 mL132.3346 mL
5 mM0.5293 mL2.6467 mL5.2934 mL26.4669 mL
10 mM0.2647 mL1.3233 mL2.6467 mL13.2335 mL
20 mM0.1323 mL0.6617 mL1.3233 mL6.6167 mL
50 mM0.0529 mL0.2647 mL0.5293 mL2.6467 mL
100 mM0.0265 mL0.1323 mL0.2647 mL1.3233 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Ser935Ser910RadiosynthesisPositron emission tomographyPETParkinson's diseaseMouse Swiss 3T3 cellsMouse embryonic fibroblast cellsMNKMitogen activated protein kinase interacting kinaseMAPK interacting kinaseMAP kinase interacting kinaseLRRK2Leucine-rich repeat kinase 2InhibitorinhibitHG-10-102-01HG1010201HG 10 102 01HEK293 cellsBBB
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