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Dehydro Palonosetron
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Catalog No. T209513Cas No. 135729-56-5
Alias RS 42358-197
Dehydro Palonosetron (RS 42358-197) is a potent, selective, and orally active 5-HT3 receptor antagonist. It does not affect the activity of 5-HT1 receptors, 5-HT2 receptors, or 5-HT4 receptors.
Dehydro Palonosetron
😃Good
Catalog No. T209513Alias RS 42358-197Cas No. 135729-56-5
Dehydro Palonosetron (RS 42358-197) is a potent, selective, and orally active 5-HT3 receptor antagonist. It does not affect the activity of 5-HT1 receptors, 5-HT2 receptors, or 5-HT4 receptors.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dehydro Palonosetron (RS 42358-197) is a potent, selective, and orally active 5-HT3 receptor antagonist. It does not affect the activity of 5-HT1 receptors, 5-HT2 receptors, or 5-HT4 receptors. |
| In vitro | In in vitro assays, Dehydro Palonosetron (RS 42358-197) acts as a competitive antagonist, counteracting 5-HT-induced contractions in guinea pig ileum with an estimated pA2 value of 8.1. Dehydro Palonosetron shows no agonistic or antagonistic activity on 5-HT1-like receptors, 5-HT2 receptors, or 5-HT4 receptors. |
| In vivo | In anesthetized rats, Dehydro Palonosetron (RS 42358-197) was administered intravenously, intraduodenally, or transdermally, and it inhibited the 2-methyl 5-HT induced Bezold-Jarisch reflex in a dose-dependent manner, with ID50 values of 0.05 μg/kg (i.v.), 5.7 μg/kg (i.d.), and 11.6 μg/chamber. Additionally, Dehydro Palonosetron (RS 42358-197; 0.01 ng/kg-10 mg/kg; oral; single dose) reduced mouse behaviors inhibited by aversive stimuli in a light/dark test box. |
| Synonyms | RS 42358-197 |
| Molecular Weight | 294.39 |
| Formula | C19H22N2O |
| Cas No. | 135729-56-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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