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EHNA hydrochloride

Name: EHNA hydrochloride
Brand: TargetMol
SKU: T11168
Price: 99 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11168Cas No. 58337-38-5

EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.

EHNA hydrochloride

🥰Excellent

Catalog No. T11168Cas No. 58337-38-5

Pack Size	Price	Availability	Quantity
2 mg	$99	In Stock

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Product Introduction

Bioactivity

Description	EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.
Targets&IC50	PDE2A (human):0.8 μM
In vitro	EHNA hydrochloride exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity. EHNA hydrochloride prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts. EHNA hydrochloride completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity. [2]

Chemical Properties

Molecular Weight	313.83
Formula	C₁₄H₂₄ClN₅O
Cas No.	58337-38-5
Smiles	[C@H](CCCCCC)([C@@H](C)O)N1C=2C(N=C1)=C(N)N=CN2.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 80 mg/mL (254.92 mM.), Sonication is recommended.

DMSO: 60 mg/mL(191.19 mM.), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.1864 mL	15.9322 mL	31.8644 mL	159.3219 mL
5 mM	0.6373 mL	3.1864 mL	6.3729 mL	31.8644 mL
10 mM	0.3186 mL	1.5932 mL	3.1864 mL	15.9322 mL
20 mM	0.1593 mL	0.7966 mL	1.5932 mL	7.9661 mL
50 mM	0.0637 mL	0.3186 mL	0.6373 mL	3.1864 mL
100 mM	0.0319 mL	0.1593 mL	0.3186 mL	1.5932 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc