FGFR1 inhibitor-2

Name: FGFR1 inhibitor-2
Brand: TargetMol
SKU: T39992
Rating: 4.5 (1 reviews)

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Catalog No. T39992Cas No. 2410612-08-5

Alias FGFR1 inhibitor-2

FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.

FGFR1 inhibitor-2

😃Good

Catalog No. T39992Alias FGFR1 inhibitor-2Cas No. 2410612-08-5

FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$970	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	FGFR1 inhibitor-2 (with an IC50 of 4.55 μM in MDA-MB-231 cells) is a potent inhibitor of FGFR1. It is specifically useful for studying metastatic triple-negative breast cancer.
In vitro	FGFR1 inhibitor-2, when applied at concentrations of 3 and 6 μM to MDA-MB-231 cells for a duration of 48 hours, effectively diminishes FGFR1 expression, as evidenced by Western Blot Analysis[1]. Additionally, a dose-dependent increase in the apoptotic index of MDA-MB-231 cells is observed, reaching a significant 10.6-fold elevation at a concentration of 5 μM, indicating a pronounced pro-apoptotic effect at this dosage[1].
Synonyms	FGFR1 inhibitor-2

Chemical Properties

Molecular Weight	507.461
Formula	C₂₅H₂₂F₅N₃O₃
Cas No.	2410612-08-5
Smiles	Fc1ccc(cc1)C(CCCCNC(=O)Nc1ccc(c(c1)C(F)(F)F)N(=O)=O)c1ccc(F)cc1
Relative Density.	1.350 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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