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MCC-555

Name: MCC-555
Brand: TargetMol
SKU: T21764
Price: 64 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T21764Cas No. 161600-01-7

Alias Netoglitazone, Isaglitazone

MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.

MCC-555

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Purity: 99.82%

Catalog No. T21764Alias Netoglitazone, IsaglitazoneCas No. 161600-01-7

MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$64	In Stock	In Stock
10 mg	$113	In Stock	In Stock
25 mg	$238	In Stock	In Stock
50 mg	$396	In Stock	In Stock
100 mg	$589	In Stock	In Stock
500 mg	$1,280	-	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.82%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

MCC-555 AI Summary

MCC-555 exhibits a range of pharmacological activities. It demonstrates significant antidiabetic effects, reducing plasma glucose levels by 60.0% and triglycerides by 72.0% at a dosage of 30 mg/kg. Additionally, it shows anti-inflammatory properties, achieving an 18.0% reduction in inflammation at a 100 mg/kg dose in rats. Furthermore, MCC-555 has antiviral activity against SARS-CoV-2, as evidenced by its ability to inhibit the virus-induced cytotoxicity in VERO-6 cells at a concentration of 10 µM with an IC50 value greater than 20000 nM. The compound also acts as an agonist on the PPARgamma receptor, with an EC50 of 3000000 nM in an assay involving a GST-fused PPARgamma protein expressed in Escherichia coli DH5alpha..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	MCC-555 (Isaglitazone) is a PPARα and PPARγ agonist exerting antihyperglycemic effects.
Synonyms	Netoglitazone, Isaglitazone

Chemical Properties

Molecular Weight	381.42
Formula	C₂₁H₁₆FNO₃S
Cas No.	161600-01-7
Smiles	Fc1ccccc1COc1ccc2cc(CC3SC(=O)NC3=O)ccc2c1
Relative Density.	1.369g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (655.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.24 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6218 mL	13.1089 mL	26.2178 mL	131.0891 mL
5 mM	0.5244 mL	2.6218 mL	5.2436 mL	26.2178 mL
10 mM	0.2622 mL	1.3109 mL	2.6218 mL	13.1089 mL
20 mM	0.1311 mL	0.6554 mL	1.3109 mL	6.5545 mL
50 mM	0.0524 mL	0.2622 mL	0.5244 mL	2.6218 mL
100 mM	0.0262 mL	0.1311 mL	0.2622 mL	1.3109 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc