Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

Anti-IGF1R/CD221 Antibody (1V195)

😃Good
Catalog No. TMAY-00383
Alias JTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221

Anti-IGF1R/CD221 Antibody (1V195) is a Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody (1V195) can be used in FCM,ICC/IF.

Anti-IGF1R/CD221 Antibody (1V195)

Anti-IGF1R/CD221 Antibody (1V195)

😃Good
Catalog No. TMAY-00383Alias JTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221
Anti-IGF1R/CD221 Antibody (1V195) is a Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody (1V195) can be used in FCM,ICC/IF.
Pack SizePriceAvailabilityQuantity
100 μL$270 7-10 days
Bulk & Custom
Add to Cart
Questions
View More
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Anti-IGF1R/CD221 Antibody (1V195) is a Rabbit antibody targeting IGF1R/CD221. Anti-IGF1R/CD221 Antibody (1V195) can be used in FCM,ICC/IF.
AliasJTK13, insulin-like growth factor 1 receptor, IGFR, IGFIR, IGF-I R, IGF1 Receptor, CD221
Ig Type
Monoclonal Rabbit IgG
Clone
1V195
Reactivity
Human
Verified Activity
1. Immunofluorescence staining of Human IGF1R in MCF7 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with Rabbit anti-Human IGF1R monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to cell membrane.

2. Flow cytometric analysis of human IGF1R expression on HeLa cells. Cells were stained with purified anti-Human IGF1R, then a FITC-conjugated second step antibody. The histogram were derived from events with the forward and side light-scatter characteristics of intact cells.
Application
FCM,ICC/IF
Recommended Dose
ICC-IF: 1:20-1:100; FCM: 1:25-1:100
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human IGF1R / CD221 (rh IGF1R / CD221; TMPY-00834; NP_000866.1; Met1-Asn932).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundThe insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain, and a cytoplasmic tyrosine kinase domain. The IGF1R signaling pathway is activated in the mammalian nervous system from the early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signaling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumors and mediates proliferation and apoptosis protection. IGF signaling also influences hypoxia signaling, protease secretion, tumor cell motility, and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, IGF1R is now an attractive anti-cancer treatment target.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Others Formats
APC/FITC/PE
Antibody Types Available
4
Antigen Details
Immunogen
Recombinant Human IGF1R / CD221 protein (TMPY-00834)
Antigen Species
Human
Biology Area
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

Sci Citations

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy Anti-IGF1R/CD221 Antibody (1V195) | purchase Anti-IGF1R/CD221 Antibody (1V195) | Anti-IGF1R/CD221 Antibody (1V195) cost | order Anti-IGF1R/CD221 Antibody (1V195)