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SGC-CBP30

Name: SGC-CBP30
Brand: TargetMol
SKU: T6668
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T6668Cas No. 1613695-14-9

SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).

SGC-CBP30

🥰Excellent

Purity: 99.05%

Catalog No. T6668Cas No. 1613695-14-9

SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).

Pack Size	Price	Availability
1 mg	$45	In Stock
2 mg	$65	In Stock
5 mg	$80	In Stock
10 mg	$122	In Stock
25 mg	$222	In Stock
50 mg	$372	In Stock
100 mg	$556	In Stock
1 mL x 10 mM (in DMSO)	$90	In Stock

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Batch Information

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Purity:99.05%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).
Targets&IC50	EP300:38 nM, CREBBP:21 nM
In vivo	SGC-CBP30 exhibits moderate cytotoxicity in U2OS and HeLa cells.

Chemical Properties

Molecular Weight	509.04
Formula	C₂₈H₃₃ClN₄O₃
Cas No.	1613695-14-9
Smiles	COc1ccc(CCc2nc3cc(ccc3n2C[C@H](C)N2CCOCC2)-c2c(C)noc2C)cc1Cl
Relative Density.	1.28 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (182.7 mM), Sonication is recommended.

DMSO: 93 mg/mL (182.7 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9645 mL	9.8224 mL	19.6448 mL	98.2241 mL
5 mM	0.3929 mL	1.9645 mL	3.9290 mL	19.6448 mL
10 mM	0.1964 mL	0.9822 mL	1.9645 mL	9.8224 mL
20 mM	0.0982 mL	0.4911 mL	0.9822 mL	4.9112 mL
50 mM	0.0393 mL	0.1964 mL	0.3929 mL	1.9645 mL
100 mM	0.0196 mL	0.0982 mL	0.1964 mL	0.9822 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc