Polyketomycin

Name: Polyketomycin
Brand: TargetMol
SKU: T12517
Rating: 4.5 (1 reviews)

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Catalog No. T12517Cas No. 200625-47-4

Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities.

Polyketomycin

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Catalog No. T12517Cas No. 200625-47-4

Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities.

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25 mg	$1,520	Inquiry	Inquiry

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Product Introduction

Bioactivity

Description	Polyketomycin, a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, exhibits antibacterial, anticancer, and antimalarial activities.
In vitro	Polyketomycin demonstrates inhibitory activity against a spectrum of cancers, including L1210 leukemia, EL-4 leukemia, P388 leukemia, Ehrlich carcinoma, IMC carcinoma, colon 26 adenocarcinoma, Meth A fibrosarcoma, FS-3 fibrosarcoma, and B16-BL10 melanoma, with respective IC50 values of 3.3 μg/mL, 2.1 μg/mL, 5.2 μg/mL, 1 μg/mL, 0.9 μg/mL, 1.8 μg/mL, 2.4 μg/mL, 1.5 μg/mL, and 1.6 μg/mL[1].
In vivo	In mice, Polyketomycin acute toxicity is estimated to be 6.25-12.5mg/kg[1].

Chemical Properties

Molecular Weight	864.84
Formula	C₄₄H₄₈O₁₈
Cas No.	200625-47-4
Smiles	O[C@]12[C@](O)(C(=O)C=3C(C1)=C(C)C4=C(C3O)C(=O)C=C(OC)C4=O)C(=O)/C(=C(\C)/O)/C(=O)[C@H]2O[C@@H]5O[C@H](C)[C@@H](O[C@H]6C[C@@](C)(O)[C@H](OC(=O)C7=C(O)C(C)=CC=C7C)[C@H](C)O6)CC5
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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