Shopping Cart

Your shopping cart is currently empty

Piperonylic acid

Name: Piperonylic acid
Brand: TargetMol
SKU: TN6848
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. TN6848Cas No. 94-53-1

Alias 2H-1,3-benzodioxole-5-carboxylic acid

Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73A P450 subpopulation.

Piperonylic acid

Copy Product Info

🥰Excellent

Purity: 99.93%

Catalog No. TN6848Alias 2H-1,3-benzodioxole-5-carboxylic acidCas No. 94-53-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.93%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Piperonylic acid AI Summary

Piperonylic acid exhibits a diverse range of bioactivities. It functions as an inhibitor of rat alpha-glucosidase with an IC50 value of 18.4% at 50 µg/ml, and demonstrates antioxidant activity with a DPPH radical scavenging activity SC50 value of 2.4%. Additionally, it inhibits Aldehyde Dehydrogenase 1 (ALDH1A1) with a potency of 19952.6 nM and affects the ERK signaling pathway with a potency of 39810.7 nM. It also acts as an antifeedant against the pine weevil (Hylobius abietis) with an Antifeedant Index (AFI) of 14.0% at 50 mM concentration, measured after 24 hours. In terms of enzyme inhibition, Piperonylic acid inhibits CYP73A1 from Populus sieboldii x Populus grandidentata by 58.0% at 100 µM, and shows weak inhibition of trans-cinnamate 4-hydroxylase in Saccharomyces cerevisiae BJ2168 with an IC50 greater than 100,000 nM. Furthermore, it displays antiviral activity against SARS-CoV-2, although with a low potency (IC50 > 20000 nM). Lastly, the compound antagonizes human P2X receptors P2X2R, P2X4R, and P2X5R showing inhibition rates of 21.0%, 29.0%, and 10.0% respectively when tested at 50 µM concentration using a calcium influx assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Piperonylic acid (2H-1,3-benzodioxole-5-carboxylic acid) is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic acid selectively inactivate the CYP73A P450 subpopulation.
Synonyms	2H-1,3-benzodioxole-5-carboxylic acid

Chemical Properties

Molecular Weight	166.13
Formula	C₈H₆O₄
Cas No.	94-53-1
Smiles	OC(=O)C1=CC2=C(OCO2)C=C1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (331.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.04 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0194 mL	30.0969 mL	60.1938 mL	300.9691 mL
5 mM	1.2039 mL	6.0194 mL	12.0388 mL	60.1938 mL
10 mM	0.6019 mL	3.0097 mL	6.0194 mL	30.0969 mL
20 mM	0.3010 mL	1.5048 mL	3.0097 mL	15.0485 mL
50 mM	0.1204 mL	0.6019 mL	1.2039 mL	6.0194 mL
100 mM	0.0602 mL	0.3010 mL	0.6019 mL	3.0097 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc