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CDK9-IN-2

Name: CDK9-IN-2
Brand: TargetMol
SKU: T14918
Price: 80 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T14918Cas No. 1263369-28-3

CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours).

CDK9-IN-2

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Purity: 99%

Catalog No. T14918Cas No. 1263369-28-3

CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours).

Pack Size	Price	Availability
1 mg	$80	In Stock
5 mg	$197	In Stock
10 mg	$296	In Stock
25 mg	$512	In Stock
50 mg	$743	In Stock
100 mg	$1,050	In Stock
1 mL x 10 mM (in DMSO)	$217	In Stock

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This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours).
Targets&IC50	CDK9:5 nM, H929 multiple myeloma cells:
In vitro	CDK9-IN-2, at a concentration of 200 nM, decreases MEPCE expression, suggesting MEPCE serves as a pharmacodynamic indicator for CDK9 inhibitors. Moreover, MCL1 protein levels are diminished within 2 hours of CDK9-IN-2 treatment, with further reduction observed after 16 hours of exposure to a higher concentration of 500 nM.

Chemical Properties

Molecular Weight	425.93
Formula	C₂₃H₂₅ClFN₅
Cas No.	1263369-28-3
Smiles	N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1
Relative Density.	1.302 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 70 mg/mL (164.35 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3478 mL	11.7390 mL	23.4780 mL	117.3902 mL
5 mM	0.4696 mL	2.3478 mL	4.6956 mL	23.4780 mL
10 mM	0.2348 mL	1.1739 mL	2.3478 mL	11.7390 mL
20 mM	0.1174 mL	0.5870 mL	1.1739 mL	5.8695 mL
50 mM	0.0470 mL	0.2348 mL	0.4696 mL	2.3478 mL
100 mM	0.0235 mL	0.1174 mL	0.2348 mL	1.1739 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc