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Kyotorphin acetate

Name: Kyotorphin acetate
Brand: TargetMol
SKU: T20172L
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T20172L

Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.

Kyotorphin acetate

🥰Excellent

Purity: 99.88%

Catalog No. T20172L

Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.

Pack Size	Price	Availability
1 mg	$48	In Stock
2 mg	$67	In Stock
5 mg	$95	In Stock
10 mg	$158	In Stock
25 mg	$347	In Stock
50 mg	$519	In Stock
100 mg	$752	In Stock
500 mg	$1,570	In Stock
1 mL x 10 mM (in DMSO)	$142	In Stock

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Purity:99.88%

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.
In vitro	The release of immunoreactive Met-enkephalin (I-ME) from the rat striatum was studied in vitro using a batch technique. A basal release of the order of 2-3% of total I-ME tissue content per 10 min was found. Kyotorphin produced dose-dependent I-ME release, with 0.5 mM maximal concentration causing 2-3-fold stimulation of release. This release was calcium-dependent. In concentrations up to 1 mM Kyotorphin did not change the basal release of [3H]noradrenaline, [3H]GABA, [3H]D-aspartate and immunoreactive beta-endorphin from various brain structures[3].
In vivo	Kyotorphin produced a naloxone-reversible potent analgesic effect, yet no inhibitory effect on electrically induced contractions of longitudinal muscle of the guinea pig ileum[1].

Chemical Properties

Molecular Weight	397.43
Formula	C₁₇H₂₇N₅O₆
Smiles	CC(O)=O.N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)N)=O
Relative Density.	no data available
Sequence	H-Tyr-Arg-OH
Sequence Short	YR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (163.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5162 mL	12.5808 mL	25.1617 mL	125.8083 mL
5 mM	0.5032 mL	2.5162 mL	5.0323 mL	25.1617 mL
10 mM	0.2516 mL	1.2581 mL	2.5162 mL	12.5808 mL
20 mM	0.1258 mL	0.6290 mL	1.2581 mL	6.2904 mL
50 mM	0.0503 mL	0.2516 mL	0.5032 mL	2.5162 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc