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Kyotorphin acetate

Name: Kyotorphin acetate
Brand: TargetMol
SKU: T20172L
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T20172L

Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.

Kyotorphin acetate

😃Good

Purity: 99.88%

Catalog No. T20172L

Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	In Stock	In Stock
2 mg	$67	In Stock	In Stock
5 mg	$95	In Stock	In Stock
10 mg	$158	In Stock	In Stock
25 mg	$347	In Stock	In Stock
50 mg	$519	In Stock	In Stock
100 mg	$752	In Stock	In Stock
500 mg	$1,570	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$142	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.88%

Resource Download

COA LCMS

Product Introduction

Bioactivity

Description	Kyotorphin acetate is an endogenous peptide with analgesia activity and can be used as a biomarker of Alzheimer disease.
In vitro	The release of immunoreactive Met-enkephalin (I-ME) from the rat striatum was studied in vitro using a batch technique. A basal release of the order of 2-3% of total I-ME tissue content per 10 min was found. Kyotorphin produced dose-dependent I-ME release, with 0.5 mM maximal concentration causing 2-3-fold stimulation of release. This release was calcium-dependent. In concentrations up to 1 mM Kyotorphin did not change the basal release of [3H]noradrenaline, [3H]GABA, [3H]D-aspartate and immunoreactive beta-endorphin from various brain structures[3].
In vivo	Kyotorphin produced a naloxone-reversible potent analgesic effect, yet no inhibitory effect on electrically induced contractions of longitudinal muscle of the guinea pig ileum[1].

Chemical Properties

Molecular Weight	397.43
Formula	C₁₇H₂₇N₅O₆
Smiles	CC(O)=O.N=C(N)NCCC[C@@H](C(O)=O)NC([C@H](CC1=CC=C(O)C=C1)N)=O
Relative Density.	no data available
Sequence	H-Tyr-Arg-OH
Sequence Short	YR

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (163.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5162 mL	12.5808 mL	25.1617 mL	125.8083 mL
5 mM	0.5032 mL	2.5162 mL	5.0323 mL	25.1617 mL
10 mM	0.2516 mL	1.2581 mL	2.5162 mL	12.5808 mL
20 mM	0.1258 mL	0.6290 mL	1.2581 mL	6.2904 mL
50 mM	0.0503 mL	0.2516 mL	0.5032 mL	2.5162 mL
100 mM	0.0252 mL	0.1258 mL	0.2516 mL	1.2581 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc