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Pentachloropseudilin

Name: Pentachloropseudilin
Brand: TargetMol
SKU: T24612
Rating: 4.5 (1 reviews)

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Catalog No. T24612Cas No. 69640-38-6

Alias PClP, Antibiotic A 15104 Y

Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.

Pentachloropseudilin

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Purity: 98.14%

Catalog No. T24612Alias PClP, Antibiotic A 15104 YCas No. 69640-38-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.14%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
In vitro	Pentachloropseudoprotein (PCLP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and activation of the plasminogen activator inhibitor-1 (PAI-1) promoter, with an IC50 value of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells) [2]. Pentachloropseudoprotein reduced TGF-β-stimulated expression of waveform protein, N-adhesin, and fibronectin, thereby blocking TGF-β-induced epithelial-to-mesenchymal transition (EMT) in these cells. Pentachloropseudoprotein (0.05 to 1 μΜ; 0-6 hours) pretreatment inhibited the TGF-β-mediated increase in p-Smad2/3 expression (50 or 100 pM), reducing it by 47% (Mv1Lu) and 79% (A549), respectively [2]. Sucrose density gradient analysis and immunofluorescence staining showed that pentachloro pseudilin (0.2 μM) inhibited TGF-β-stimulated cellular responses by accelerating caveolae-mediated internalization, inhibiting cell surface type II TGF-β receptor expression, and then degrading the receptor primarily through lysosome-dependent degradation [2].
Synonyms	PClP, Antibiotic A 15104 Y

Chemical Properties

Molecular Weight	331.41
Formula	C₁₀H₄Cl₅NO
Cas No.	69640-38-6
Smiles	Oc1c(Cl)cc(Cl)cc1-c1[nH]c(Cl)c(Cl)c1Cl
Relative Density.	1.733g/cm3
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (241.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.96 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0174 mL	15.0871 mL	30.1741 mL	150.8705 mL
5 mM	0.6035 mL	3.0174 mL	6.0348 mL	30.1741 mL
10 mM	0.3017 mL	1.5087 mL	3.0174 mL	15.0871 mL
20 mM	0.1509 mL	0.7544 mL	1.5087 mL	7.5435 mL
50 mM	0.0603 mL	0.3017 mL	0.6035 mL	3.0174 mL
100 mM	0.0302 mL	0.1509 mL	0.3017 mL	1.5087 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc