Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

Pentachloropseudilin

Name: Pentachloropseudilin
Brand: TargetMol
SKU: T24612
Rating: 4.5 (1 reviews)

Copy Product Info

😃Good

Catalog No. T24612Cas No. 69640-38-6

Alias PClP, Antibiotic A 15104 Y

Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.

Pentachloropseudilin

Copy Product Info

😃Good

Purity: 98.14%

Catalog No. T24612Alias PClP, Antibiotic A 15104 YCas No. 69640-38-6

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98.14%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Pentachloropseudilin (PClP) is a reversible variant 1 myosin inhibitor with antimicrobial activity that inhibits Myo1s and class 5 myosins.Pentachloropseudilin inhibits growth factor-beta (TGF-β), which blocks host cell invasion by Trypanosoma cruzi.
In vitro	Pentachloropseudoprotein (PCLP) inhibits TGF-β-stimulated Smad2/3 phosphorylation and activation of the plasminogen activator inhibitor-1 (PAI-1) promoter, with an IC50 value of 0.1 μM in target cells (A549, HepG2, and Mv1Lu cells) [2]. Pentachloropseudoprotein reduced TGF-β-stimulated expression of waveform protein, N-adhesin, and fibronectin, thereby blocking TGF-β-induced epithelial-to-mesenchymal transition (EMT) in these cells. Pentachloropseudoprotein (0.05 to 1 μΜ; 0-6 hours) pretreatment inhibited the TGF-β-mediated increase in p-Smad2/3 expression (50 or 100 pM), reducing it by 47% (Mv1Lu) and 79% (A549), respectively [2]. Sucrose density gradient analysis and immunofluorescence staining showed that pentachloro pseudilin (0.2 μM) inhibited TGF-β-stimulated cellular responses by accelerating caveolae-mediated internalization, inhibiting cell surface type II TGF-β receptor expression, and then degrading the receptor primarily through lysosome-dependent degradation [2].
Synonyms	PClP, Antibiotic A 15104 Y

Chemical Properties

Molecular Weight	331.41
Formula	C₁₀H₄Cl₅NO
Cas No.	69640-38-6
Smiles	Oc1c(Cl)cc(Cl)cc1-c1[nH]c(Cl)c(Cl)c1Cl
Relative Density.	1.733g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (241.39 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 3.3 mg/mL (9.96 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0174 mL	15.0871 mL	30.1741 mL	150.8705 mL
5 mM	0.6035 mL	3.0174 mL	6.0348 mL	30.1741 mL
10 mM	0.3017 mL	1.5087 mL	3.0174 mL	15.0871 mL
20 mM	0.1509 mL	0.7544 mL	1.5087 mL	7.5435 mL
50 mM	0.0603 mL	0.3017 mL	0.6035 mL	3.0174 mL
100 mM	0.0302 mL	0.1509 mL	0.3017 mL	1.5087 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc