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CU-CPT9b

Name: CU-CPT9b
Brand: TargetMol
SKU: T7302
Price: 44 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T7302Cas No. 2162962-69-6

Alias TLR8-specific antagonist 1, CU-CPT-9b

CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

CU-CPT9b

🥰Excellent

Purity: 98.1%

Catalog No. T7302Alias TLR8-specific antagonist 1, CU-CPT-9bCas No. 2162962-69-6

Pack Size	Price	Availability
1 mg	$44	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$272	In Stock
50 mg	$378	In Stock
100 mg	$559	In Stock
200 mg	$796	In Stock
1 mL x 10 mM (in DMSO)	$113	In Stock

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Batch Information

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Purity:98.1%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	CU-CPT9b (TLR8-specific antagonist 1) is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.
Targets&IC50	TLR8:0.7 nM (IC50), TLR8:21 nM (Kd)
Synonyms	TLR8-specific antagonist 1, CU-CPT-9b

Chemical Properties

Molecular Weight	251.28
Formula	C₁₆H₁₃NO₂
Cas No.	2162962-69-6
Smiles	Cc1cc(ccc1O)-c1ccnc2cc(O)ccc12
Relative Density.	1.287 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (397.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.9796 mL	19.8981 mL	39.7962 mL	198.9812 mL
5 mM	0.7959 mL	3.9796 mL	7.9592 mL	39.7962 mL
10 mM	0.3980 mL	1.9898 mL	3.9796 mL	19.8981 mL
20 mM	0.1990 mL	0.9949 mL	1.9898 mL	9.9491 mL
50 mM	0.0796 mL	0.3980 mL	0.7959 mL	3.9796 mL
100 mM	0.0398 mL	0.1990 mL	0.3980 mL	1.9898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc