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Anti-TRIM63 Antibody (5C208)

(Synonyms: Tripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63) Copy Product Info
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Synonyms: Tripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63

Catalog No. TMAC-02688 Copy Product Info
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Anti-TRIM63 Antibody (5C208) is a Mouse antibody targeting TRIM63. Anti-TRIM63 Antibody (5C208) can be used in FCM,ICC,IHC.
Anti-TRIM63 Antibody
(5C208)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2967-10 days7-10 days
100 μL$4987-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-TRIM63 Antibody (5C208) is a Mouse antibody targeting TRIM63. Anti-TRIM63 Antibody (5C208) can be used in FCM,ICC,IHC.
SynonymsTripartite motif-containing protein 63, TRIM 63, Striated muscle RING zinc finger protein, SMRZ, RNF 28, RING-type E3 ubiquitin transferase TRIM63, Muscle-specific RING finger protein 1 (MuRF-1, MuRF1), MuRF1, Iris RING finger protein, IRF, E3 ubiquitin-protein ligase TRIM63
Clone
5C208
Reactivity
Human
Application
Recommended Dose
IHC: 1:50-200; ICC: 1:50-200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundMuscle specific RING finger protein (MuRF1) is a sarcomere-associated protein that is upregulated by conditions that provoke atrophy. Pharmacological or genetic inhibition of the IKKbeta/NF-kappaB/MuRF1 pathway reverses muscle atrophy, which presents MuRF as a target for clinical intervention. MuRF1 is a key regulator of the PKC-dependent hypertrophic response and can blunt cardiomyocyte hypertrophy, which may have important implications in the pathophysiology of clinical cardiac hypertrophy. MuRF1 directly associates with Titin kinase and influences microtubule-dependent signaling pathways in striated muscle and iris. MuRF1 upregulation is an indicator for skeletal muscle atrophy mechanisms that utilize ubiquitin-dependent proteolysis. MuRF1 transcript levels are high in situations where there is an overabundance of reactive oxygen species, such as cancer, AIDS and sepsis.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 40 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Related Tags: Anti-TRIM63 Antibody (5C208) molecular weight