Shopping Cart

Your shopping cart is currently empty

BI-1347

Name: BI-1347
Brand: TargetMol
SKU: T5405
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T5405Cas No. 2163056-91-3

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.

BI-1347

Copy Product Info

😃Good

Purity: 99.63%

Catalog No. T5405Cas No. 2163056-91-3

BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$253	In Stock	In Stock
50 mg	$463	In Stock	In Stock
100 mg	$682	In Stock	In Stock
500 mg	$1,430	-	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.63%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

BI-1347 AI Summary

BI-1347 shows a broad spectrum of bioactivities, including inhibition of tau aggregation induced by a specific mutant tau, and inhibition of CDK8/CyclinC with a low IC50 value, demonstrating high binding affinity to CDK8. These features suggest potential therapeutic applications in neurodegenerative diseases and cancer. Moreover, this compound exhibits inhibitory activity against the SARS-CoV-2 3CL-Pro protease, with an inhibition percentage of -21.58% at a concentration of 20µM in a FRET assay and hinders SARS-CoV-2 induced cytotoxicity in VERO-6 cells at 10µM. It also influences cell viability in a cell-type-specific manner, demonstrating both positive and negative effects on the growth rates of HEK293T, U2OS, and human fibroblast cells. Additionally, the compound affects the thermal stability of various protein domains, increasing or decreasing their stability selectively. These diverse bioactivities underline the compound's potential as a multi-target therapeutic agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.
Targets&IC50	CDK8:1 nM (cell free)

Chemical Properties

Molecular Weight	356.42
Formula	C₂₂H₂₀N₄O
Cas No.	2163056-91-3
Smiles	CN(C)C(=O)Cn1cc(cn1)-c1ccc(cc1)-c1cncc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 120 mg/mL (336.68 mM), Sonication and heating are recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (11.22 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8057 mL	14.0284 mL	28.0568 mL	140.2839 mL
5 mM	0.5611 mL	2.8057 mL	5.6114 mL	28.0568 mL
10 mM	0.2806 mL	1.4028 mL	2.8057 mL	14.0284 mL
20 mM	0.1403 mL	0.7014 mL	1.4028 mL	7.0142 mL
50 mM	0.0561 mL	0.2806 mL	0.5611 mL	2.8057 mL
100 mM	0.0281 mL	0.1403 mL	0.2806 mL	1.4028 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc