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CLEFMA

Name: CLEFMA
Brand: TargetMol
SKU: T9582
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9582Cas No. 1246964-32-8

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

CLEFMA

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Purity: 99.00%

Catalog No. T9582Cas No. 1246964-32-8

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$62	-	In Stock
5 mg	$141	-	In Stock
10 mg	$209	-	In Stock
25 mg	$333	-	In Stock
50 mg	$475	-	In Stock
100 mg	$638	-	In Stock
200 mg	$833	-	In Stock
1 mL x 10 mM (in DMSO)	$161	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.00%

Appearance:Solid

Color:Yellow

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
Targets&IC50	A549 cells:8.9 μM, H441 cells:6.4 μM
In vitro	CLEFMA induces autophagic death in H441 cells[1]. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2]. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].
In vivo	Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model [2]. In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID [2].

Chemical Properties

Molecular Weight	442.29
Formula	C₂₃H₁₇Cl₂NO₄
Cas No.	1246964-32-8
Smiles	C(=C\1/C(=O)\C(=C\C2=C(Cl)C=CC=C2)\CN(C(/C=C\C(O)=O)=O)C1)\C3=C(Cl)C=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (135.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2610 mL	11.3048 mL	22.6096 mL	113.0480 mL
5 mM	0.4522 mL	2.2610 mL	4.5219 mL	22.6096 mL
10 mM	0.2261 mL	1.1305 mL	2.2610 mL	11.3048 mL
20 mM	0.1130 mL	0.5652 mL	1.1305 mL	5.6524 mL
50 mM	0.0452 mL	0.2261 mL	0.4522 mL	2.2610 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc