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CLEFMA

Name: CLEFMA
Brand: TargetMol
SKU: T9582
Price: 62 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9582Cas No. 1246964-32-8

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

CLEFMA

🥰Excellent

Purity: 99.00%

Catalog No. T9582Cas No. 1246964-32-8

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

Pack Size	Price	Availability
1 mg	$62	In Stock
5 mg	$141	In Stock
10 mg	$209	In Stock
25 mg	$333	In Stock
50 mg	$475	In Stock
100 mg	$638	In Stock
200 mg	$833	In Stock
1 mL x 10 mM (in DMSO)	$161	In Stock

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Purity:99.00%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.
Targets&IC50	A549 cells:8.9 μM, H441 cells:6.4 μM
In vitro	CLEFMA induces autophagic death in H441 cells[1]. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2]. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].
In vivo	Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model [2]. In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID [2].

Chemical Properties

Molecular Weight	442.29
Formula	C₂₃H₁₇Cl₂NO₄
Cas No.	1246964-32-8
Smiles	C(=C\1/C(=O)\C(=C\C2=C(Cl)C=CC=C2)\CN(C(/C=C\C(O)=O)=O)C1)\C3=C(Cl)C=CC=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (135.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2610 mL	11.3048 mL	22.6096 mL	113.0480 mL
5 mM	0.4522 mL	2.2610 mL	4.5219 mL	22.6096 mL
10 mM	0.2261 mL	1.1305 mL	2.2610 mL	11.3048 mL
20 mM	0.1130 mL	0.5652 mL	1.1305 mL	5.6524 mL
50 mM	0.0452 mL	0.2261 mL	0.4522 mL	2.2610 mL
100 mM	0.0226 mL	0.1130 mL	0.2261 mL	1.1305 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc