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Synta66

Name: Synta66
Brand: TargetMol
SKU: T13047
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13047Cas No. 835904-51-3

Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.

Synta66

🥰Excellent

Purity: 99.84%

Catalog No. T13047Cas No. 835904-51-3

Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$30	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$253	In Stock	In Stock
100 mg	$377	In Stock	In Stock
200 mg	$536	-	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.84%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.
In vitro	Synta66 is an Orai inhibitor, which forms the pore of the CRAC channel. Synta66 (10 μM) suppresses human platelet activation in plasma, whole-blood thrombus formation, and inhibits the LAD2 human mast cell line.

Chemical Properties

Molecular Weight	352.36
Formula	C₂₀H₁₇FN₂O₃
Cas No.	835904-51-3
Smiles	COc1ccc(OC)c(c1)-c1ccc(NC(=O)c2ccncc2F)cc1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (141.9 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (7.1 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8380 mL	14.1900 mL	28.3801 mL	141.9003 mL
5 mM	0.5676 mL	2.8380 mL	5.6760 mL	28.3801 mL
10 mM	0.2838 mL	1.4190 mL	2.8380 mL	14.1900 mL
20 mM	0.1419 mL	0.7095 mL	1.4190 mL	7.0950 mL
50 mM	0.0568 mL	0.2838 mL	0.5676 mL	2.8380 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	1.4190 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc