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Anti-HGF/SF Antibody (TAK-701)
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Catalog No. T9901A-1423
Alias TAK-701
Anti-HGF/SF Antibody (TAK-701) represents a highly specialized humanized monoclonal antibody specifically engineered to target the human hepatocyte growth factor which acts as a pivotal ligand for the c-Met receptor tyrosine kinase across various malignancies, effectively facilitating the measurable neutralization of HGF-induced signaling to evaluate its role in cancer cell survival and metastasis during strictly monitored laboratory observation periods.
Anti-HGF/SF Antibody (TAK-701)
Anti-HGF/SF Antibody (TAK-701)
Copy Product Info🥰Excellent
Catalog No. T9901A-1423Alias TAK-701
Anti-HGF/SF Antibody (TAK-701) represents a highly specialized humanized monoclonal antibody specifically engineered to target the human hepatocyte growth factor which acts as a pivotal ligand for the c-Met receptor tyrosine kinase across various malignancies, effectively facilitating the measurable neutralization of HGF-induced signaling to evaluate its role in cancer cell survival and metastasis during strictly monitored laboratory observation periods.
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| Description | Anti-HGF/SF Antibody (TAK-701) represents a highly specialized humanized monoclonal antibody specifically engineered to target the human hepatocyte growth factor which acts as a pivotal ligand for the c-Met receptor tyrosine kinase across various malignancies, effectively facilitating the measurable neutralization of HGF-induced signaling to evaluate its role in cancer cell survival and metastasis during strictly monitored laboratory observation periods. |
| In vitro | In co-culture assays using NSCLC cell lines and HGF-secreting fibroblasts, Anti-HGF/SF Antibody (TAK-701) blocked HGF-induced c-MET phosphorylation and reversed gefitinib resistance [1]. |
| In vivo | In mouse models of NSCLC with tumor-derived HGF, systemic administration of Anti-HGF/SF Antibody (TAK-701) suppressed tumor growth and enhanced the efficacy of EGFR inhibitors [1]. |
| Synonyms | TAK-701 |
| Clone | TAK-701 |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | HGF/SF |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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