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Anti-TROP-2 Antibody (2M375)
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Catalog No. TMAY-00817
Alias tumor-associated calcium signal transducer 2, TROP-2, TROP2, TACD2, M1S1, GP50, GA733-1, GA7331, EGP-1, EGP1
Anti-TROP-2 Antibody (2M375) is a Rabbit antibody targeting TROP-2. Anti-TROP-2 Antibody (2M375) can be used in ICC/IF.
Anti-TROP-2 Antibody (2M375)
Anti-TROP-2 Antibody (2M375)
😃Good
Catalog No. TMAY-00817Alias tumor-associated calcium signal transducer 2, TROP-2, TROP2, TACD2, M1S1, GP50, GA733-1, GA7331, EGP-1, EGP1
Anti-TROP-2 Antibody (2M375) is a Rabbit antibody targeting TROP-2. Anti-TROP-2 Antibody (2M375) can be used in ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ICC/IF Reactivity: Human, Rhesus, Cynomolgus |
| Alias | tumor-associated calcium signal transducer 2, TROP-2, TROP2, TACD2, M1S1, GP50, GA733-1, GA7331, EGP-1, EGP1 |
| Ig Type | Rabbit IgG |
| Clone | 2M375 |
| Reactivity | Human, Rhesus, Cynomolgus;
Not React with: Mouse, Rat |
| Verified Activity | 1. Immunofluorescence staining of TROP2 in SKBR3 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-human TROP2 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Cell membrane. 2. Immunofluorescence staining of TROP-2 in NCI-N87 cells. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-Human TROP-2 monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cell membrane. |
| Application | ICC/IF |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human TROP2/TACSTD2 (rh TROP2/TACSTD2; TMPY-01262; NP_002344.2; Met1-Thr274). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | TROP-2, also referred to as tumor-associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, which are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human TROP2/TACSTD2 Protein (TMPY-01262) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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