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Bufuralol

Name: Bufuralol
Brand: TargetMol
SKU: T30611
Price: 390 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T30611Cas No. 54340-62-4

Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787

Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.

Bufuralol

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Purity: 98.26%

Catalog No. T30611Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787Cas No. 54340-62-4

Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$390	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.26%

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COA

Product Introduction

Bioactivity

Description	Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.
In vitro	Bufuralol is a widely used substrate for assessing cytochrome P450 2D6 (CYP2D6) enzyme activity. By measuring the rate of metabolism of Bufuralol, the level of CYP2D6 activity in an individual or cell can be effectively assessed. [1]
In vivo	The metabolism of Bufuralol is mediated by NADPH-dependent cytochrome P450 enzymes (specifically CYP2D6) and exhibits biphasic kinetics. The metabolic efficiency of Bufuralol was significantly increased in the intestines of monkeys in the presence of hydroperoxyisopropylbenzene (CuOOH). The metabolism of Bufuralol exhibited biphasic kinetics mediated by NADPH and was more efficient in the presence of CuOOH, which was consistent with observations in the liver. [2]
Synonyms	Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787

Chemical Properties

Molecular Weight	261.36
Formula	C₁₆H₂₃NO₂
Cas No.	54340-62-4
Smiles	OC(C=1OC2=C(C=CC=C2CC)C1)CNC(C)(C)C
Relative Density.	1.066 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (306.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8261 mL	19.1307 mL	38.2614 mL	191.3070 mL
5 mM	0.7652 mL	3.8261 mL	7.6523 mL	38.2614 mL
10 mM	0.3826 mL	1.9131 mL	3.8261 mL	19.1307 mL
20 mM	0.1913 mL	0.9565 mL	1.9131 mL	9.5654 mL
50 mM	0.0765 mL	0.3826 mL	0.7652 mL	3.8261 mL
100 mM	0.0383 mL	0.1913 mL	0.3826 mL	1.9131 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc