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Bufuralol

Name: Bufuralol
Brand: TargetMol
SKU: T30611
Rating: 4.5 (1 reviews)

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Catalog No. T30611Cas No. 54340-62-4

Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787

Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.

Bufuralol

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Purity: 99.99%

Catalog No. T30611Alias Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787Cas No. 54340-62-4

Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 mg	$399	1-2 weeks	1-2 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Bufuralol (Ro 3-4787) is an orally active β-adrenergic receptor blocker with a certain degree of sympathomimetic effects and can be used to study cardiovascular diseases.
In vitro	Bufuralol is a widely used substrate for assessing cytochrome P450 2D6 (CYP2D6) enzyme activity. By measuring the rate of metabolism of Bufuralol, the level of CYP2D6 activity in an individual or cell can be effectively assessed. [1]
In vivo	The metabolism of Bufuralol is mediated by NADPH-dependent cytochrome P450 enzymes (specifically CYP2D6) and exhibits biphasic kinetics. The metabolic efficiency of Bufuralol was significantly increased in the intestines of monkeys in the presence of hydroperoxyisopropylbenzene (CuOOH). The metabolism of Bufuralol exhibited biphasic kinetics mediated by NADPH and was more efficient in the presence of CuOOH, which was consistent with observations in the liver. [2]
Synonyms	Ro3-4787, Ro-3-4787, Ro 3-4787, RO 034787

Chemical Properties

Molecular Weight	261.36
Formula	C₁₆H₂₃NO₂
Cas No.	54340-62-4
Smiles	OC(C=1OC2=C(C=CC=C2CC)C1)CNC(C)(C)C
Relative Density.	1.066 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (306.09 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (12.63 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8261 mL	19.1307 mL	38.2614 mL	191.3070 mL
5 mM	0.7652 mL	3.8261 mL	7.6523 mL	38.2614 mL
10 mM	0.3826 mL	1.9131 mL	3.8261 mL	19.1307 mL
20 mM	0.1913 mL	0.9565 mL	1.9131 mL	9.5654 mL
50 mM	0.0765 mL	0.3826 mL	0.7652 mL	3.8261 mL
100 mM	0.0383 mL	0.1913 mL	0.3826 mL	1.9131 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc