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TC-DAPK 6

Name: TC-DAPK 6
Brand: TargetMol
SKU: T17004
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17004Cas No. 315694-89-4

TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.

TC-DAPK 6

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Purity: 98.73%

Catalog No. T17004Cas No. 315694-89-4

TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.

Pack Size	Price	Availability
5 mg	$32	In Stock
10 mg	$52	In Stock
25 mg	$98	In Stock
50 mg	$139	In Stock
100 mg	$198	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock

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Batch Information

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Purity:98.73%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	TC-DAPK 6 is an ATP-competitive inhibitor of Death-associated protein kinase (DAPK) with IC50s of 69 and 225 nM for DAPK1 and DAPK3.
Targets&IC50	DAPK1:69 nM, DAPK3:225 nM
In vitro	TC-DAPK 6 inhibits p70S6K with IC50s of 1 μM-10 μM[1].

Chemical Properties

Molecular Weight	276.29
Formula	C₁₇H₁₂N₂O₂
Cas No.	315694-89-4
Smiles	C(=C1C(=O)OC(C=CC2=CC=CC=C2)=N1)C=3C=CC=NC3
Relative Density.	1.18 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.8 mg/mL (60.8 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.6194 mL	18.0969 mL	36.1939 mL	180.9693 mL
5 mM	0.7239 mL	3.6194 mL	7.2388 mL	36.1939 mL
10 mM	0.3619 mL	1.8097 mL	3.6194 mL	18.0969 mL
20 mM	0.1810 mL	0.9048 mL	1.8097 mL	9.0485 mL
50 mM	0.0724 mL	0.3619 mL	0.7239 mL	3.6194 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc