store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 373.00 | |
5 mg | In stock | $ 895.00 | |
10 mg | In stock | $ 1,270.00 | |
25 mg | In stock | $ 1,980.00 | |
50 mg | In stock | $ 2,780.00 | |
100 mg | In stock | $ 3,520.00 |
Description | AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer. |
Targets&IC50 | cGMP:50 nM (EC50s), cAMP:17 nM (EC50s) |
In vitro |
AZD5462 (example 1) exhibits stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively[1]. Binding to human plasma proteins with a fraction unbound (free) rate of 4.3%, AZD5462 demonstrates stability with Clint values of 23 μL/min/mg (human liver microsomal), 4.8 μL/min/10^6 cells (human hepatocyte), and 11 μL/min/10^6 cells (rat hepatocyte)[1]. AZD5462 enhances the phosphorylation of ERK with an EC50 value of 6.3 nM[1]. |
Molecular Weight | 544.65 |
Formula | C30H41FN2O6 |
CAS No. | 2787501-83-9 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (91.8 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AZD5462 2787501-83-9 GPCR/G Protein RXFP receptor inhibitor inhibit