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AZD5462

Name: AZD5462
Brand: TargetMol
SKU: T63838
Price: 373 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T63838Cas No. 2787501-83-9

AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

AZD5462

🥰Excellent

Purity: 99.63%

Catalog No. T63838Cas No. 2787501-83-9

AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.

Pack Size	Price	Availability
1 mg	$373	In Stock
5 mg	$895	In Stock
10 mg	$1,270	In Stock
25 mg	$1,980	In Stock
50 mg	$2,780	In Stock
100 mg	$3,520	In Stock

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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.63%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	AZD5462 is a potent orally available relaxin receptor RXFP1 agonist for the study of heart failure and cancer.
Targets&IC50	cAMP:17 nM (EC50s), cGMP:50 nM (EC50s)
In vitro	AZD5462 (example 1) exhibits stimulatory activity on cAMP or cGMP production with EC50s of 17 nM and 50 nM, respectively[1]. Binding to human plasma proteins with a fraction unbound (free) rate of 4.3%, AZD5462 demonstrates stability with Clint values of 23 μL/min/mg (human liver microsomal), 4.8 μL/min/10^6 cells (human hepatocyte), and 11 μL/min/10^6 cells (rat hepatocyte)[1]. AZD5462 enhances the phosphorylation of ERK with an EC50 value of 6.3 nM[1].

Chemical Properties

Molecular Weight	544.65
Formula	C₃₀H₄₁FN₂O₆
Cas No.	2787501-83-9
Smiles	C(NCC1(C)CCC1)(=O)[C@@H]2[C@H](NC(=O)C3=C(OC)C=C(F)C(O[C@H]4CC[C@](C(O)=O)(C)CC4)=C3)[C@@]5(C[C@]2(CC5)[H])[H]
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (91.8 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8360 mL	9.1802 mL	18.3604 mL	91.8021 mL
5 mM	0.3672 mL	1.8360 mL	3.6721 mL	18.3604 mL
10 mM	0.1836 mL	0.9180 mL	1.8360 mL	9.1802 mL
20 mM	0.0918 mL	0.4590 mL	0.9180 mL	4.5901 mL
50 mM	0.0367 mL	0.1836 mL	0.3672 mL	1.8360 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc