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INCB086550

Name: INCB086550
Brand: TargetMol
SKU: T36899
Price: 148 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T36899Cas No. 2230911-59-6

Alias PD-1/PD-L1-IN-8

INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.

INCB086550

🥰Excellent

Purity: 98.49%

Catalog No. T36899Alias PD-1/PD-L1-IN-8Cas No. 2230911-59-6

INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.

Pack Size	Price	Availability
1 mg	$148	In Stock
5 mg	$378	In Stock
10 mg	$568	In Stock
25 mg	$913	In Stock
50 mg	$1,230	In Stock
100 mg	$1,680	In Stock

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Batch Information

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Purity:98.49%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	INCB086550 (PD-1/PD-L1-IN-8) (example 24) is a PD-1/PD-L1 inhibitor, with an IC50 <= 10 nM.
Synonyms	PD-1/PD-L1-IN-8

Chemical Properties

Molecular Weight	693.79
Formula	C₄₁H₃₉N₇O₄
Cas No.	2230911-59-6
Smiles	Cc1c(Nc2nccc3cc(CN4CC[C@@H](O)C4)cnc23)cccc1-c1cccc(-c2nc3cc(CN4CC[C@H](C4)C(O)=O)cc(C#N)c3o2)c1C
Relative Density.	1.42 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 75.6 mg/mL (109 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.4414 mL	7.2068 mL	14.4136 mL	72.0679 mL
5 mM	0.2883 mL	1.4414 mL	2.8827 mL	14.4136 mL
10 mM	0.1441 mL	0.7207 mL	1.4414 mL	7.2068 mL
20 mM	0.0721 mL	0.3603 mL	0.7207 mL	3.6034 mL
50 mM	0.0288 mL	0.1441 mL	0.2883 mL	1.4414 mL
100 mM	0.0144 mL	0.0721 mL	0.1441 mL	0.7207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc