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RET-IN-23

🥰Excellent
Catalog No. T79099Cas No. 2479961-46-9

RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.

RET-IN-23

RET-IN-23

🥰Excellent
Purity: 97.46%
Catalog No. T79099Cas No. 2479961-46-9
RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.
Pack SizePriceAvailabilityQuantity
1 mg$293In Stock
5 mg$722In Stock
10 mg$987In Stock
25 mg$1,520In Stock
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:97.46%
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Product Introduction

Bioactivity
Description
RET-IN-23 is an orally available and highly potent RET inhibitor with significant antitumor activity for the study of non-small cell lung cancer.
Targets&IC50
RET (M918T):1.47 nM, RET (V804M):1.03 nM, RET (CCDC6):2.50 nM, RET (V804L):6.54 nM, RET (WT):1.32 nM
In vitro
RET-IN-23 is a potent and orally active RET inhibitor with IC50 of 1.32, 2.50, 6.54, 1.03, and 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, and RET-M918T, respectively. [1]
In vivo
RET-IN-23 exhibited significant antitumor activity in mice after oral administration at a dose of 5 mg/kg. [1]
Chemical Properties
Molecular Weight537.59
FormulaC28H28FN11
Cas No.2479961-46-9
SmilesFC=1C=NN(C1)C2=NC=C(C=C2)CN3C4CN(C5=NC=C(C=C5)C6=NC(=CC(=N6)C)NC7=NNC(=C7)C)CC3C4
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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