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Quinacrine (dihydrochloride hydrate)

Name: Quinacrine (dihydrochloride hydrate)
Brand: TargetMol
SKU: T23210
Rating: 4.5 (1 reviews)

(Synonyms: Quinacrine hydrochloride hydrate (83-89-6 free base)) Copy Product Info

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Synonyms: Quinacrine hydrochloride hydrate (83-89-6 free base)

Catalog No. T23210 Copy Product Info

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Quinacrine dihydrochloride hydrate possesses antiprotozoal and anti-infective properties and exhibits multi-target biological activity; it inhibits voltage-gated sodium channels (which are involved in the generation and conduction of action potentials) and aldehyde oxidase activity, and acts as a riboflavin antagonist to interfere with riboflavin-related protein interactions; Furthermore, quinacrine has been used in in vitro models to study the regulation of prion misfolding processes.

Cas No. 207671-43-0

Pack Size	Price	USA Stock	Global Stock	Quantity
500 mg	$50	Inquiry	Inquiry
1 g	$56	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Quinacrine dihydrochloride hydrate possesses antiprotozoal and anti-infective properties and exhibits multi-target biological activity; it inhibits voltage-gated sodium channels (which are involved in the generation and conduction of action potentials) and aldehyde oxidase activity, and acts as a riboflavin antagonist to interfere with riboflavin-related protein interactions; Furthermore, quinacrine has been used in in vitro models to study the regulation of prion misfolding processes.
In vitro	Quinacrine dihydrochloride hydrate (0–20 μM, 24 h) inhibits the growth of SGC-7901 cells and induces apoptosis [3].
In vivo	Quinacrine dihydrochloride hydrate (3–30 mg/kg, intraperitoneally, once daily for three consecutive days) exerts a protective effect against glycerol-induced acute kidney injury in rats [2].
Synonyms	Quinacrine hydrochloride hydrate (83-89-6 free base)

Chemical Properties

Molecular Weight	472.9
Formula	C₂₃H₃₀ClN₃O·2HCl·xH₂O
Cas No.	207671-43-0
Smiles	ClC1=CC=C2C(NC(C)CCCN(CC)CC)=C3C(C=CC(OC)=C3)=NC2=C1.Cl.Cl.O
Relative Density.	no data available

Storage & Solubility Information

Storage

Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 9.33 mg/mL (19.73 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1146 mL	10.5731 mL	21.1461 mL	105.7306 mL
5 mM	0.4229 mL	2.1146 mL	4.2292 mL	21.1461 mL
10 mM	0.2115 mL	1.0573 mL	2.1146 mL	10.5731 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Keywords

Quinacrine (hydrochloride hydrate) (83-89-6 free base)Quinacrine (hydrochloride hydrate)Quinacrinedihydrochloride Hydrate83-89-6 free base83-89-6

Related Tags: Quinacrine (dihydrochloride hydrate) chemical structure | Quinacrine (dihydrochloride hydrate) in vivo | Quinacrine (dihydrochloride hydrate) in vitro | Quinacrine (dihydrochloride hydrate) formula | Quinacrine (dihydrochloride hydrate) molecular weight