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UK-124114

Name: UK-124114
Brand: TargetMol
SKU: T0124
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0124Cas No. 165108-07-6

Alias UNII-A2669OWX9N, Selamectin

UK-124114 (Selamectin) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.

UK-124114

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Purity: 99.64%

Catalog No. T0124Alias UNII-A2669OWX9N, SelamectinCas No. 165108-07-6

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	In Stock	In Stock
5 mg	$118	In Stock	In Stock
10 mg	$175	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$432	In Stock	In Stock
100 mg	$639	In Stock	-

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.64%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	UK-124114 (Selamectin) is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. In an H. contortus larval development assay, selamectin (0.1 μg/ml) shows the effect of growth inhibition.
In vivo	A single administration of 6 mg/kg topical selamectin given every two months could effectively prevent B. malayi infection.?Application of topical selamectin twice a year could block circulating microfilariae.?Since there are no treatment guidelines currently available for lymphatic filarial infection in cats, the data obtained from this study could be used to guide the management of brugian lymphatic filarial infection in reservoir cats[3].
Synonyms	UNII-A2669OWX9N, Selamectin

Chemical Properties

Molecular Weight	769.96
Formula	C₄₃H₆₃NO₁₁
Cas No.	165108-07-6
Smiles	O[C@@]1\2[C@]3(C(=NO)C(C)=C[C@]1(C(=O)O[C@@]4(C[C@@]5(O[C@@H]([C@@H](C)CC5)[C@H]6CCCCC6)O[C@@](C4)(C/C=C(\C)/[C@@H](O[C@H]7C[C@H](OC)[C@@H](O)[C@H](C)O7)[C@@H](C)/C=C\C=C2\CO3)[H])[H])[H])[H]
Relative Density.	1.35g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (64.94 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2988 mL	6.4938 mL	12.9877 mL	64.9384 mL
5 mM	0.2598 mL	1.2988 mL	2.5975 mL	12.9877 mL
10 mM	0.1299 mL	0.6494 mL	1.2988 mL	6.4938 mL
20 mM	0.0649 mL	0.3247 mL	0.6494 mL	3.2469 mL
50 mM	0.0260 mL	0.1299 mL	0.2598 mL	1.2988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc