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PROTAC FKBP Degrader-3

Name: PROTAC FKBP Degrader-3
Brand: TargetMol
SKU: T18610
Rating: 4.5 (1 reviews)

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Catalog No. T18610Cas No. 2079056-43-0

PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].

PROTAC FKBP Degrader-3

😃Good

Catalog No. T18610Cas No. 2079056-43-0

PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].

Pack Size	Price	Availability
1 mg	$493	10-14 weeks
5 mg	$993	10-14 weeks
10 mg	$1,490	10-14 weeks
25 mg	$2,190	10-14 weeks
50 mg	$2,980	10-14 weeks
100 mg	$3,950	10-14 weeks

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Product Introduction

Bioactivity

Description

PROTAC FKBP Degrader-3 is a potent FKBP degrader, consisting of a FKBP ligand binding group, a linker, and a VHL binding group [1].

In vitro

Treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) notably enhanced the polyubiquitination of EGFP-FKBP within the first hour, indicating its efficacy in promoting VHL-related protein degradation. This process involves the recruitment of endogenous VHL by PROTAC FKBP Degrader-3 (compound 10), during which ubiquitination was observed specifically at one background lysine residue (Lys158) of EGFP[1].

Chemical Properties

Molecular Weight	1295.54
Formula	C₆₈H₉₀N₆O₁₇S
Cas No.	2079056-43-0
Relative Density.	1.233 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc