Shopping Cart

Remove All

Your shopping cart is currently empty

Proceed to checkout Continue shopping

PROTAC FKBP Degrader-3

Name: PROTAC FKBP Degrader-3
Brand: TargetMol
SKU: T18610
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T18610Cas No. 2079056-43-0

PROTAC FKBP Degrader-3 is a bifunctional PROTAC molecule composed of an FKBP ligand-binding group, a rationally designed linker, and a VHL E3 ligase-binding moiety, and functions as a potent FKBP degrader, enabling selective protein degradation studies and validation of FKBP as a therapeutic target.

PROTAC FKBP Degrader-3

😃Good

Catalog No. T18610Cas No. 2079056-43-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$493	10-14 weeks	10-14 weeks
5 mg	$993	10-14 weeks	10-14 weeks
10 mg	$1,490	10-14 weeks	10-14 weeks
25 mg	$2,190	10-14 weeks	10-14 weeks
50 mg	$2,980	10-14 weeks	10-14 weeks
100 mg	$3,950	10-14 weeks	10-14 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description

In vitro

Treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) notably enhanced the polyubiquitination of EGFP-FKBP within the first hour, indicating its efficacy in promoting VHL-related protein degradation. This process involves the recruitment of endogenous VHL by PROTAC FKBP Degrader-3 (compound 10), during which ubiquitination was observed specifically at one background lysine residue (Lys158) of EGFP[1].

Chemical Properties

Molecular Weight	1295.54
Formula	C₆₈H₉₀N₆O₁₇S
Cas No.	2079056-43-0
Smiles	[C@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(OCC(NCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)=CC=C3)=O)CCCC1)(CC)C7=CC(OC)=C(OC)C(OC)=C7
Relative Density.	1.233 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (15.44 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7719 mL	3.8594 mL	7.7188 mL	38.5939 mL
5 mM	0.1544 mL	0.7719 mL	1.5438 mL	7.7188 mL
10 mM	0.0772 mL	0.3859 mL	0.7719 mL	3.8594 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc