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PROTAC FKBP Degrader-3

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Catalog No. T18610Cas No. 2079056-43-0

PROTAC FKBP Degrader-3 is a bifunctional PROTAC molecule composed of an FKBP ligand-binding group, a rationally designed linker, and a VHL E3 ligase-binding moiety, and functions as a potent FKBP degrader, enabling selective protein degradation studies and validation of FKBP as a therapeutic target.

PROTAC FKBP Degrader-3

PROTAC FKBP Degrader-3

😃Good
Catalog No. T18610Cas No. 2079056-43-0
PROTAC FKBP Degrader-3 is a bifunctional PROTAC molecule composed of an FKBP ligand-binding group, a rationally designed linker, and a VHL E3 ligase-binding moiety, and functions as a potent FKBP degrader, enabling selective protein degradation studies and validation of FKBP as a therapeutic target.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$49310-14 weeks10-14 weeks
5 mg$99310-14 weeks10-14 weeks
10 mg$1,49010-14 weeks10-14 weeks
25 mg$2,19010-14 weeks10-14 weeks
50 mg$2,98010-14 weeks10-14 weeks
100 mg$3,95010-14 weeks10-14 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
PROTAC FKBP Degrader-3 is a bifunctional PROTAC molecule composed of an FKBP ligand-binding group, a rationally designed linker, and a VHL E3 ligase-binding moiety, and functions as a potent FKBP degrader, enabling selective protein degradation studies and validation of FKBP as a therapeutic target.
In vitro
Treatment with 250 nM of PROTAC FKBP Degrader-3 (compound 10) notably enhanced the polyubiquitination of EGFP-FKBP within the first hour, indicating its efficacy in promoting VHL-related protein degradation. This process involves the recruitment of endogenous VHL by PROTAC FKBP Degrader-3 (compound 10), during which ubiquitination was observed specifically at one background lysine residue (Lys158) of EGFP[1].
Chemical Properties
Molecular Weight1295.54
FormulaC68H90N6O17S
Cas No.2079056-43-0
Smiles[C@H](C(=O)N1[C@H](C(O[C@H](CCC2=CC(OC)=C(OC)C=C2)C3=CC(OCC(NCCOCCOCCOCC(N[C@H](C(=O)N4[C@H](C(NCC5=CC=C(C=C5)C=6SC=NC6C)=O)C[C@@H](O)C4)C(C)(C)C)=O)=O)=CC=C3)=O)CCCC1)(CC)C7=CC(OC)=C(OC)C(OC)=C7
Relative Density.1.233 g/cm3 (Predicted)
Storage & Solubility Information
StorageIn solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 20 mg/mL (15.44 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.7719 mL3.8594 mL7.7188 mL38.5939 mL
5 mM0.1544 mL0.7719 mL1.5438 mL7.7188 mL
10 mM0.0772 mL0.3859 mL0.7719 mL3.8594 mL

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Keywords

VHLPROTAC FKBP Degrader-3PROTAC FKBP Degrader3PROTAC FKBP Degrader 3FKBP
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