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TOPK

T-LAK cell-originated protein kinase (TOPK) is a MAPKK-like kinase which plays a role in cell cycle regulation and mitotic progression. As a consequence, TOPK expression is minimal in differentiated cells, although its overexpression is a pathophysiological feature of many tumours. Hence, TOPK has garnered interest as a cancer-specific biomarker and biochemical target with the potential to enhance cancer therapy whilst causing minimal harm to normal tissues.

  • OTS964 hydrochloride
    T41351338545-07-5
    OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.
    • $38
    In Stock
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    TargetMol | Citations Cited
  • Cephradine
    T019938821-53-3
    Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
    • $29
    In Stock
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  • OTS514 hydrochloride
    T41342319647-76-0
    OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
    • $56
    In Stock
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  • HI-TOPK-032
    T15481487020-03-1
    HI-TOPK-032 is an effective and specific inhibitor of TOPK.
    • $39
    In Stock
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  • Ilaprazole
    T1756L172152-36-2
    Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the development of reflux oesophagitis.
    • $39
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  • Ilaprazole sodium
    T1756172152-50-0
    Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus of the gastric parietal cell where it is converted to an active sulfenamide form that binds to cysteine sulfhydryl groups on the luminal aspect of the proton pump hydrogen-potassium adenosine triphosphatase (H+/K+ ATPase), thereby inhibiting the pump's activity and the parietal cell secretion of H+ ions into the gastric lumen, the final step in gastric acid production.
    • $31
    In Stock
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  • OTS514
    T4134L1338540-63-8
    OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed the growth of SCLC cell lines (IC50: 0.4 ~ 42.6 nM). Treatment with OTS514 suppressed forkhead box protein M1 (FOXM1) activity. OTS514 treatment reduced CD90-positive SCLC cells and showed a higher cytotoxic effect against lung sphere-derived CSC-like SCLC cells.
    • $89
    5 days
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