Shopping Cart

Your shopping cart is currently empty

Prednicarbate

Name: Prednicarbate
Brand: TargetMol
SKU: T21443
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T21443Cas No. 73771-04-7

Alias UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollient

Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibiting the production of vasodilators such as nitric oxide and prostacyclin.

Prednicarbate

Copy Product Info

😃Good

Purity: 99.88%

Catalog No. T21443Alias UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollientCas No. 73771-04-7

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$30	-	In Stock
10 mg	$48	-	In Stock
25 mg	$89	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$32	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.88%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Prednicarbate AI Summary

Prednicarbate exhibits a diverse range of bioactivities. Notably, it demonstrates a high potency in inhibiting Chronic Active B-Cell Receptor Signaling with a value of 5.2 nM and shows a potency of 58.0 nM in the Nrf2 screening assay, which is confirmed in the Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation. Additionally, it inhibits the AmpC Beta-Lactamase enzyme with a potency of 79,432.8 nM in the presence of a detergent and HP1-beta Chromodomain interactions with methylated histone tails at 100,000.0 nM. Prednicarbate also acts as an inhibitor in the primary qHTS for delayed death of the malarial parasite plastid with a potency of 18,526.0 nM and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells both without and with CPT present, showing potencies of 16,066.6 nM and 12,762.2 nM, respectively. The compound has a bioactivity profile suggesting a low risk of drug-induced liver injury, with all measured Hepatic Side Effect (HepSE) scores in the DILIps training set reported as 0.0. This includes scores for bilirubinemia, cholecystitis, cirrhosis, hepatitis, and abnormal liver function tests among others, along with a combined HepSE score of 0.0, highlighting its low potential for hepatic side effects. In antiviral assays, Prednicarbate shows bioactivity in inhibiting cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1) with an inhibition index of 1.368, indicating higher activity than the arbidol control. However, its IC50 value in the inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells is greater than 20,000.0 nM, pointing to relatively low potency in this context. Additionally, Prednicarbate has high binding affinity (> 10,000.0 nM) towards various receptors such as human ADRB1, ADRB2, SLC6A3, OPRK1, ADORA1, ADRA1A, and others. It shows agonist activity at human OPRM1, HRH2, DRD1, PGR, HTR2A, and antagonist activity at CHRM2, HTR1A, ADRA2A, HTR2A, and HTR2B. It has a significant affinity for the human NR1I2 receptor with an AC50 value of 17.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Prednicarbate (Hoe 777) is a Corticosteroid Hormone Receptor Agonist. Prednicarbate has antipruritic, anti-inflammatory, and vasoconstrictive properties. It also decreases the number of circulating lymphocytes by inhibiting the production of vasodilators such as nitric oxide and prostacyclin.
Synonyms	UNII-V901LV1K7D, Hoe-777, Hoe 777, Dermatop E emollient

Chemical Properties

Molecular Weight	488.57
Formula	C₂₇H₃₆O₈
Cas No.	73771-04-7
Smiles	C(COC(CC)=O)(=O)[C@]1(OC(OCC)=O)[C@]2(C)[C@@](CC1)([C@]3([C@]([C@@H](O)C2)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])[H]
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 10 mg/mL (20.47 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0468 mL	10.2339 mL	20.4679 mL	102.3395 mL
5 mM	0.4094 mL	2.0468 mL	4.0936 mL	20.4679 mL
10 mM	0.2047 mL	1.0234 mL	2.0468 mL	10.2339 mL
20 mM	0.1023 mL	0.5117 mL	1.0234 mL	5.1170 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc