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GW7647

Name: GW7647
Brand: TargetMol
SKU: T15453
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15453Cas No. 265129-71-3

GW 7647 is an effective and highly selective PPARα agonist, the EC 50 values of human PPARα, PPARγ and PPARδ receptors are 6,1100 and 6200 nM, respectively. GW 7647 can reduce the production of nitric oxide in macrophages and has lipid-lowering and anti-inflammatory properties in the body.

GW7647

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Purity: 99.34%

Catalog No. T15453Cas No. 265129-71-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$45	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$150	In Stock	In Stock
25 mg	$256	In Stock	In Stock
50 mg	$441	In Stock	In Stock
100 mg	$636	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	GW 7647 is an effective and highly selective PPARα agonist, the EC 50 values of human PPARα, PPARγ and PPARδ receptors are 6,1100 and 6200 nM, respectively. GW 7647 can reduce the production of nitric oxide in macrophages and has lipid-lowering and anti-inflammatory properties in the body.
Targets&IC50	PPARγ:1.1 μM (EC50)( Human PPARγ), PPARα:6 nM (EC50)( Human PPARα), PPARδ:6.2 μM (EC50)( Human PPARδ)
In vitro	GW7647 at a concentration of 50 nM, promotes PI3K and Akt (Ser473) phosphorylation, leading to an increase in NOS1 phosphorylation and subsequently elevating NO levels in stripped antral mucosa. Additionally, at the same concentration, it boosts the initial phase of Ca2+-mediated exocytotic events triggered by ACh in antral mucous cells, without independently inducing any exocytotic events. At a higher concentration of 1 μM, GW7647 substantially elevates PDZK1 protein levels to 129.7 ± 6.5% compared to controls in Caco2BBE cells, irrespective of IL-1β presence, and mitigates the IL-1β-induced reduction in PDZK1 expression. When combined with ACh, GW7647 augments the impact of wortmannin (50 nM) and AKT-inh (100 nM) on exocytotic activity in these cells. At 100 nM, GW7647 significantly decreases AQP9 protein levels by 43% in WIF-B9 hepatocytes and by 24% in HepG2 cells, though it shows no notable effects at 10 and 1,000 nM in WIF-B9 hepatocytes, nor does it significantly affect L-FABP protein levels in HepG2 hepatocytes.
In vivo	GW7647 (3 mg/kg per day) does not prevent cardiac hypertrophy but preserves left ventricular ejection fraction in vivo [4].

Chemical Properties

Molecular Weight	502.75
Formula	C₂₉H₄₆N₂O₃S
Cas No.	265129-71-3
Smiles	CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC2CCCCC2)cc1)C(O)=O
Relative Density.	1.12 g/cm3

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 81.67 mg/mL (162.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.98 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9891 mL	9.9453 mL	19.8906 mL	99.4530 mL
5 mM	0.3978 mL	1.9891 mL	3.9781 mL	19.8906 mL
10 mM	0.1989 mL	0.9945 mL	1.9891 mL	9.9453 mL
20 mM	0.0995 mL	0.4973 mL	0.9945 mL	4.9727 mL
50 mM	0.0398 mL	0.1989 mL	0.3978 mL	1.9891 mL
100 mM	0.0199 mL	0.0995 mL	0.1989 mL	0.9945 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc