Home Tools
Log in
Cart

LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated

Catalog No. TMPJ-00250
Synonyms: transforming growth factor β1, TGFβ, CED, TGFB, TGFbeta, LAP (TGFβ 1), DPD1, LAP (TGFbeta 1), LAP (TGF-β 1), transforming growth factor beta 1, LAP, LAP (TGF-beta 1), TGFB1

Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
Pack Size Availability Price/USD Quantity
20 μg 5 days $ 355.00
100 μg 5 days $ 963.00
Bulk Inquiry
Get quote
Contact us for more batch information
Biological Description
Technical Params
Product Properties
Description Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
Species Human
Expression System Human Cells
Tag N-6His-Avi
Accession Number P01137
Synonyms transforming growth factor β1, TGFβ, CED, TGFB, TGFbeta, LAP (TGFβ 1), DPD1, LAP (TGFbeta 1), LAP (TGF-β 1), transforming growth factor beta 1, LAP, LAP (TGF-beta 1), TGFB1
Amino Acid Leu30-Arg278
Construction Biotinylated Recombinant Human Latency-associated Peptide (Transforming Growth Factor Beta-1) is produced by our Mammalian expression system and the target gene encoding Leu30-Arg278 (Cys33Ser) is expressed with a 6His, Avi tag at the N-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 35-45 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.

Research Background Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.

Calculator

Reconstitution Calculator
Recombinant Proteins Dilute Calculator
Specific Activity Calculator
=
÷
X
=
X
(Unit/mg)
= 106 ÷
ng/mL

bottom

Tech Support

Please read the User Guide of Recombinant Proteins for more specific information.

Keywords

LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated transforming growth factor β1 TGFβ CED TGFB TGFbeta DPD 1 LAP (TGFβ 1) transforming growth factor b 1 DPD1 DPD-1 TGF-beta 1 transforming growth factor β 1 TGFβ 1 LAP (TGFbeta 1) TGFbeta 1 LAP (TGF-β 1) TGFB 1 TGF-b 1 TGF-β 1 TGFB-1 transforming growth factor beta 1 LAP LAP (TGF-beta 1) TGFB1 recombinant recombinant-proteins proteins protein

 

TargetMol