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LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated
(Synonyms: transforming growth factor β1, transforming growth factor beta 1, TGFβ, TGFbeta, TGFB1, TGFB, LAP (TGF-β 1), LAP (TGFβ 1), LAP (TGF-beta 1), LAP (TGFbeta 1), LAP, DPD1, CED) Copy Product InfoSynonyms: transforming growth factor β1, transforming growth factor beta 1, TGFβ, TGFbeta, TGFB1, TGFB, LAP (TGF-β 1), LAP (TGFβ 1), LAP (TGF-beta 1), LAP (TGFbeta 1), LAP, DPD1, CED
Catalog No. TMPJ-00250 Copy Product Info
Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $129 | - | In Stock | |
| 10 μg | $213 | - | In Stock | |
| 20 μg | $355 | - | In Stock | |
| 50 μg | $625 | 7-10 days | 7-10 days | |
| 100 μg | $963 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:> 90% as determined by Bis-Tris PAGE
Appearance:Lyophilized powder
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Immobilized Human ITGAV&ITGB6, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human LAP (TGF beta 1) , His Tag with the EC50 of 0.11 μg/ml determined by ELISA (QC Test). |
| Description | Transforming growth factor beta (TGFβ) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGFβ gene product. Extracellular activation of these complexes is a critical step in regulation of TGFβ function in vivo. The TGFβ1 LAP is a ligand for the integrin αvβ6 and that αvβ6-expressing cells induce spatially restricted activition of TGFβ1. And LAP identifies a novel CD4+/CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | N-His-Avi |
| Accession Number | P01137 |
| Amino Acid | Leu30-Arg278 (C33S) |
| Construction | Leu30-Arg278 (C33S) |
| Protein Purity | > 90% as determined by Bis-Tris PAGE |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Reconstitute the lyophilized protein in distilled water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Synonyms | transforming growth factor β1, transforming growth factor beta 1, TGFβ, TGFbeta, TGFB1, TGFB, LAP (TGF-β 1), LAP (TGFβ 1), LAP (TGF-beta 1), LAP (TGFbeta 1), LAP, DPD1, CED |
| Research Background |
| Molecular Weight | 31.4 kDa (Predicted); 45-50 KDa (reducing condition) |
| Storage | Store at low temperature Lyophilized powder: -20~-80°C for 1 year | Solution: -80°C for 6 months |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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Related Tags: LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated chemical structure | LAP (TGF-beta 1) Protein, Human, Recombinant (His & Avi), Biotinylated molecular weight
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