Shopping Cart

Your shopping cart is currently empty

Cinchonidine

Name: Cinchonidine
Brand: TargetMol
SKU: T1317
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

😃Good

Catalog No. T1317Cas No. 485-71-2

Alias α-Quinidine, L-Cinchonidine

Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.

Cinchonidine

Copy Product Info

😃Good

Purity: 99.87%

Catalog No. T1317Alias α-Quinidine, L-CinchonidineCas No. 485-71-2

Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$32	-	In Stock
5 g	$44	-	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.87%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Cinchonidine AI Summary

Cinchonidine exhibits a broad spectrum of bioactivities, prominently including potent antimalarial properties. It is notably effective against multiple strains of Plasmodium falciparum, exhibiting IC50 values of 91.0 nM and 40.0 nM for chloroquine-resistant and sensitive strains, respectively, as measured by [3H]hypoxanthine incorporation. Additionally, it demonstrates in vitro inhibition of parasite development in Plasmodium falciparum W2 with IC50 values ranging from 290.0 nM to 380.0 nM. The compound also inhibits heme polymerization with an IC50 of 27000.0 nM, and beta-hematin formation, indicating a potential anti-malarial mechanism. Beyond its antimalarial capabilities, Cinchonidine has shown activity against various biological targets. It inhibits the development of Trypanosoma brucei brucei with an IC50 of 18.28 µg/mL, and Leishmania mexicana with an IC50 of 5.74 µg/mL. It also possesses mild cytotoxicity towards human WI38 cells (IC50 > 68030.0 nM) and demonstrates a selectivity index of > 71.0 for human cells in comparison to Plasmodium falciparum. Cinchonidine also displays antimicrobial activity, demonstrating inhibition of AmpC Beta-Lactamase with a potency of 7943.3 nM, as well as delayed death inhibition of the malarial parasite plastid with IC50 values of 73.8 nM (96-hour incubation) and 147.2 nM (48-hour incubation). In terms of antiviral activity, Cinchonidine inhibits the cytotoxicity induced by SARS-CoV-2 in VERO-6 cells and Caco-2 cells, with a measured inhibition rate of 0.01% at 10 µM and 16.54% inhibition of the SARS-CoV-2 3CL-Pro protease enzymatic activity at 20 µM. Additionally, it shows mild inhibitory effects on electric eel acetylcholinesterase (AChE) and minimal inhibition of horse butyrylcholinesterase (BChE). These diverse bioactivities suggest that Cinchonidine holds potential for multi-target therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Cinchonidine (L-Cinchonidine) is an alkaloid extracted from Cinchona officinalis. It is a pseudo-enantiomer and stereoisomer of cinchonine.
Targets&IC50	sEH:4.2 μM (Ki), SERT I172M (human):36 μM (Ki), SERT S438T (human):196 μM (Ki), SERT Y95F (human):15 μM (Ki), dSERT:330 μM (Ki)
Synonyms	α-Quinidine, L-Cinchonidine

Chemical Properties

Molecular Weight	294.39
Formula	C₁₉H₂₂N₂O
Cas No.	485-71-2
Smiles	[C@H](O)([C@]1([N@@]2C[C@H](C=C)[C@](C1)(CC2)[H])[H])C=3C4=C(N=CC3)C=CC=C4
Relative Density.	1.0863 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 8.57 mg/mL (29.11 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 55 mg/mL (186.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (3.4 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.3969 mL	16.9843 mL	33.9685 mL	169.8427 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL	33.9685 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL	16.9843 mL
20 mM	0.1698 mL	0.8492 mL	1.6984 mL	8.4921 mL

Ethanol

	1mg	5mg	10mg	50mg
50 mM	0.0679 mL	0.3397 mL	0.6794 mL	3.3969 mL
100 mM	0.0340 mL	0.1698 mL	0.3397 mL	1.6984 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc