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Luzindole

Name: Luzindole
Brand: TargetMol
SKU: T15795
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15795Cas No. 117946-91-5

Alias N-0774

Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1.

Luzindole

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Purity: 98.53%

Catalog No. T15795Alias N-0774Cas No. 117946-91-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$47	In Stock	In Stock
2 mg	$64	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$148	In Stock	In Stock
25 mg	$272	In Stock	In Stock
50 mg	$388	In Stock	In Stock
100 mg	$568	In Stock	In Stock
200 mg	$812	-	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:98.53%

Appearance:Viscous

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Luzindole (N-0774) is a selective melatonin receptor antagonist that inhibits experimental autoimmune encephalomyelitis and exhibits antidepressant-like activity. It preferentially targets MT2 (Mel1b) over MT1 (Mel1a), with Ki values of 10.2 nM for human MT2 and 158 nM for MT1.
Targets&IC50	MT1 receptor:158 nM(ki), MT2 receptor:10.2 nM(ki)
In vitro	Luzindole (5-10 μg/ml) suppresses antigen-specific proliferation of the MBP-reactive LV-4 T cell line[1].
In vivo	Luzindole (30 mg/kg i.p.) decreases the time of immobility in a dose-dependent manner, the effect being more pronounced at midnight (60% reduction) than at noon (39% reduction). Luzindole (30 mg/kg; i.p.; days 0-5) inhibits experimental autoimmune encephalomyelitis[2]. Luzindole (30 mg/kg i.p.) did not modify the time of immobility either at noon or midnight in the albino ND/4 mouse, or in the C57BL/6J mouse, which does not produce melatonin[3]. The effect of luzindole is time-dependent, showing a maximal effect at 60 min. The anti-immobility effect of luzindole (10 mg/kg i.p.) is prevented by the administration of melatonin (30 mg/kg i.p.).
Synonyms	N-0774

Chemical Properties

Molecular Weight	292.37
Formula	C₁₉H₂₀N₂O
Cas No.	117946-91-5
Smiles	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2ccccc12
Relative Density.	1.1045 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (342.03 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.68 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4203 mL	17.1016 mL	34.2032 mL	171.0162 mL
5 mM	0.6841 mL	3.4203 mL	6.8406 mL	34.2032 mL
10 mM	0.3420 mL	1.7102 mL	3.4203 mL	17.1016 mL
20 mM	0.1710 mL	0.8551 mL	1.7102 mL	8.5508 mL
50 mM	0.0684 mL	0.3420 mL	0.6841 mL	3.4203 mL
100 mM	0.0342 mL	0.1710 mL	0.3420 mL	1.7102 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Luzindole

Luzindole

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