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Anti-E-Cadherin/Cadherin-1 Antibody (7M374)

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Catalog No. TMAC-01220

Anti-E-Cadherin/Cadherin-1 Antibody (7M374) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (7M374) can be used in WB,ICC,IHC,FCM.

Anti-E-Cadherin/Cadherin-1 Antibody (7M374)

Anti-E-Cadherin/Cadherin-1 Antibody (7M374)

😃Good
Catalog No. TMAC-01220
Anti-E-Cadherin/Cadherin-1 Antibody (7M374) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (7M374) can be used in WB,ICC,IHC,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2977-10 days
100 μL$4287-10 days
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Product Introduction

Bioactivity
Description
Anti-E-Cadherin/Cadherin-1 Antibody (7M374) is a Mouse antibody targeting E-Cadherin/Cadherin-1. Anti-E-Cadherin/Cadherin-1 Antibody (7M374) can be used in WB,ICC,IHC,FCM.
Reactivity
Human,Mouse
Application
Recommended Dose
WB: 1:500-1000; IHC: 1:200; ICC: 1:200; FCM: 1:50-100
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundE-cadherin (epithelial) is the most well-studied member of the cadherin family. It consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain contains a highly-phosphorylated region vital to beta-catenin binding and, therefore, to E-cadherin function. Loss of E-cadherin function or expression has been implicated in cancer progression and metastasis. E-cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to diagnose different kinds of breast cancer.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 130 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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