Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact UsQuotation
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Proceed to checkoutContinue shopping
TOPRelated productsBioactivityChemical infoStorage&SolubilityCalculator

10-Deacetyl-7-xylosyl paclitaxel

🥰Excellent
Catalog No. T5749Cas No. 90332-63-1
Alias 7-Xylosyl-10-deacetyltaxol, 10-Deacetyltaxol 7-Xyloside, 10-Deacetylpaclitaxel 7-Xyloside, 10-Deacetyl-7-xylosyltaxol

10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.

10-Deacetyl-7-xylosyl paclitaxel

10-Deacetyl-7-xylosyl paclitaxel

🥰Excellent
Purity: 99.76%
Catalog No. T5749Alias 7-Xylosyl-10-deacetyltaxol, 10-Deacetyltaxol 7-Xyloside, 10-Deacetylpaclitaxel 7-Xyloside, 10-Deacetyl-7-xylosyltaxolCas No. 90332-63-1
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
Pack SizePriceAvailabilityQuantity
5 mg$50In Stock
1 mL x 10 mM (in DMSO)$95In Stock
Add to Cart
Add to Quotation
Bulk & Custom
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Questions
View More

Batch Information

Select Batch
Purity:99.76%
Contact us for more batch information

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity
Description
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer.
In vitro
10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1].
In vivo
10-Deacetyl-7-xylosyl paclitaxel is an active compound used in traditional Chinese medicine to treat cancer.10-Deacetyl-7-xylosyl paclitaxel through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 10-Deacetyl-7-xylosyl paclitaxel transport (16.3±6.3×10 (-6)cm/s; n=3) suggests that the drug may still be effectively absorbed in the intestinal tract[2].
Synonyms7-Xylosyl-10-deacetyltaxol, 10-Deacetyltaxol 7-Xyloside, 10-Deacetylpaclitaxel 7-Xyloside, 10-Deacetyl-7-xylosyltaxol
Chemical Properties
Molecular Weight943.98
FormulaC50H57NO17
Cas No.90332-63-1
SmilesCC(=O)O[C@@]12CO[C@@H]1C[C@H](O[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O)[C@]1(C)[C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C
Relative Density.1.46 g/cm3
ColorWhite
Appearancesolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 25 mg/mL (26.48 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (2.12 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.0593 mL5.2967 mL10.5934 mL52.9672 mL
5 mM0.2119 mL1.0593 mL2.1187 mL10.5934 mL
10 mM0.1059 mL0.5297 mL1.0593 mL5.2967 mL
20 mM0.0530 mL0.2648 mL0.5297 mL2.6484 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

MicrotubuleAssociatedMicrotubule/TubulinMicrotubule AssociatedInhibitorinhibitADCCytotoxinADC PayloadADC Cytotoxin10-Deacetyl-7-xylosyl paclitaxel10Deacetyl7xylosyl paclitaxel10 Deacetyl 7 xylosyl paclitaxel
Related Tags: buy 10-Deacetyl-7-xylosyl paclitaxel | purchase 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel cost | order 10-Deacetyl-7-xylosyl paclitaxel | 10-Deacetyl-7-xylosyl paclitaxel chemical structure | 10-Deacetyl-7-xylosyl paclitaxel in vivo | 10-Deacetyl-7-xylosyl paclitaxel in vitro | 10-Deacetyl-7-xylosyl paclitaxel formula | 10-Deacetyl-7-xylosyl paclitaxel molecular weight
TargetMol | Logo

Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.