Triphala is an Ayurvedic polyherbal formulation. Triphala inhibits NF-κB activation. Triphala exerts antifungal action, and with anti-adipogenic, anti-inflammatory, and antineoplastic activities.

In the 3T3-L1 cell line, Triphala plays a crucial role in regulating adipogenesis by modulating the expression of adipogenic genes. It significantly mitigates adipogenesis by decreasing lipid accumulation and suppressing adipogenic gene expression. Specifically, cells treated with Triphala show approximately 1.43-, 1.67-, and 2.5-fold reductions in lipid content at concentrations of 1, 10, and 100 μg/mL, respectively, compared to controls treated with an induction cocktail alone. This regulation occurs through the downregulation of adipogenic genes, effectively preventing adipogenesis. Additionally, Triphala reduces the expression of inflammatory mediators, including IL-17, COX-2, and RANKL, by inhibiting NF-κB activation. It also demonstrates antifungal efficacy against Aspergillus species, inhibiting fungal growth by up to 37.96% in vitro.