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KB SRC 4

Name: KB SRC 4
Brand: TargetMol
SKU: T11745
Price: 238 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11745Cas No. 1380088-03-8

KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.

KB SRC 4

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Purity: 99.34%

Catalog No. T11745Cas No. 1380088-03-8

KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$64	In Stock	In Stock
5 mg	$162	In Stock	In Stock
10 mg	$238	-	In Stock
25 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$188	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.34%

Appearance:Solid

Color:White to Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	KB SRC 4 is a selective and potent c-Src inhibitor with antitumour activity that inhibits the growth of cancer cells.
Targets&IC50	c-Src:44 nM (Ki), c-Src:86 nM (Kd)
In vitro	KB SRC 4 is a highly selective c-Src inhibitor. The Kd for c-Src (86 nM) is consistent with the Ki obtained in our biochemical activity assay. Compound 4(KB SRC 4) exhibits selectivity among Src family members, with >2-fold selectivity over both Lck and Fgr, 8-fold selectivity over c-Yes, and >40-fold selectivity over Lyn, Hck, and Fyn.[1].

Chemical Properties

Molecular Weight	555.03
Formula	C₃₂H₂₃ClN₈
Cas No.	1380088-03-8
Smiles	Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1Cc1cccc(c1)-c1ccccc1
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (144.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8017 mL	9.0085 mL	18.0170 mL	90.0852 mL
5 mM	0.3603 mL	1.8017 mL	3.6034 mL	18.0170 mL
10 mM	0.1802 mL	0.9009 mL	1.8017 mL	9.0085 mL
20 mM	0.0901 mL	0.4504 mL	0.9009 mL	4.5043 mL
50 mM	0.0360 mL	0.1802 mL	0.3603 mL	1.8017 mL
100 mM	0.0180 mL	0.0901 mL	0.1802 mL	0.9009 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc