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HDAC6-IN-11
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Catalog No. T61044Cas No. 2409072-27-9
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with an IC50 value of 20.7 nM, demonstrating over 300-fold selectivity against other isoforms [1], and exhibits anti-proliferative activities against cancer cells.
HDAC6-IN-11
😃Good
Catalog No. T61044Cas No. 2409072-27-9
HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with an IC50 value of 20.7 nM, demonstrating over 300-fold selectivity against other isoforms [1], and exhibits anti-proliferative activities against cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks | 6-8 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HDAC6-IN-11 (Compound 9) is a selective HDAC6 inhibitor with an IC50 value of 20.7 nM, demonstrating over 300-fold selectivity against other isoforms [1], and exhibits anti-proliferative activities against cancer cells. |
| Targets&IC50 | HDAC6:20.7 nM, HDAC8:7750 nM |
| In vitro | HDAC6-IN-11 treatment, at concentrations ranging from 0.44-6.68 μM over 48 hours, exhibits anti-proliferative effects on A549 and HCT116 cells, reducing their proliferation rates with half-maximal inhibitory concentrations (GI50) of 3.2 μM for A549 cells and 1.82 μM for HCT116 cells, respectively [1]. Additionally, exposure to HDAC6-IN-11 across a broader concentration span of 0-20 μM for the same duration enhances the acetylation of H3 and tubulin in HCT116 cells, demonstrating a dose-dependent elevation in the acetylation levels of these proteins and notably increasing acetylated tubulin [1]. |
| Molecular Weight | 336.34 |
| Formula | C19H16N2O4 |
| Cas No. | 2409072-27-9 |
| Smiles | C(=C/C(NO)=O)\C1=NC2=C(C=C(OC3=CC=C(OC)C=C3)C=C2)C=C1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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