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c-Myc

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc.

MYCi361
T121322289690-31-7
MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).
  • $118
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MYCi975
T121332289691-01-4
MYCi975 (NUCC-0200975) is an orally active MYC inhibitor.
  • $127
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EN4
T90611197824-15-9
EN4 (EN4 MYC inhibitor) MYC inhibitor is a covalent ligand that targets cysteine 171 (C171) of MYC. It is selective for c-MYC over N-MYC and L-MYC, and inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis.
  • $32
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NY2267
T9093886053-73-2
NY2267 (Acetic acid, 2-[[6-[2-(cyclohexylamino)-1-[[(4-methoxyphenyl)methyl](2-pyridinylcarbonyl)amino]-2-oxoethyl]-2-naphthalenyl]oxy]-, 1,1-dimethylethyl ester) is a disruptor of Myc-Max interaction, with an IC50 of 36.5 μM.
  • $89
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KJ Pyr 9
T15665581073-80-5
KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).
  • $33
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MYCMI-6
T12134681282-09-7
MYCMI-6 (NSC-354961) is a potent and selective inhibitor of endogenous MYC:MAX protein interactions,reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects.
  • $68
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APTO-253
T10352916151-99-0
APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells. APTO-253 mediates anticancer activity through the induction of the KLF4 tumor suppressor.
  • $36
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10058-F4
T3048403811-55-2
10058-F4 (c-Myc Inhibitor) is a cell-permeable thiazolidinone that specifically inhibits the c-Myc-Max interaction and prevents transactivation of c-Myc target gene expression; induces cell-cycle arrest and apoptosis.
  • $43
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Mycro 3
T4367944547-46-0
Mycro 3 is potent and selective for c-Myc in whole cell assays.
  • $45
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CPI0610
T20911380087-89-7
CPI0610 (CPI-0610) is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
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    10074-G5
    T3686413611-93-5
    10074-G5 is an inhibitor of c-Myc-Max dimerization.
    • $35
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    ML327
    T42521883510-31-3
    ML327 is a MYC blocker. ML327 can also de-repress E-cadherin transcription and reverse Epithelial-to-Mesenchymal Transition (EMT).
    • $45
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    VPC-70063
    T6001913571-44-3
    VPC-70063 (Thiourea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-(phenylmethyl)-) is an inhibitor of c-Myc-MAX. VPC-70063 exhibits Myc-Max transcriptional activity inhibition of 106% with an IC50 of 8.9 μM and Myc-Max/UBE2C downstream pathway inhibition of 94%. VPC-70063 can be used for studies about anticancer.
    • $47
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    BTYNB
    T9033304456-62-0
    BTYNB (MDK6620) is an inhibitor of the oncofetal mRNA-binding protein IMP1 (IC50 = 5 μM for IMP1 binding to c-Myc mRNA). MDK6620 downregulates β-TrCP1 mRNA and reduces activation of nuclear transcriptional factors-kappa B (NF-κB). It disrupts this enhancer function by impairing IGF2 mRNA-binding protein 1 (IGF2BP1)-RNA association
    • $40
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    10074-A4
    T9628312631-87-1
    10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a “ligand cloud” around a “protein cloud”, exhibiting distinct characteristics compared to a non-binding ligand.
    • $65
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    CBP/p300-IN-2
    T107022158265-96-2
    CBP EP300-IN-2 is an inhibitor of CBP EP300 with IC50 values of 1.07 nM for CBP HTRF and 5.96 nM for Myc.
    • $2,870
    10-14 weeks
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    IRES-C11
    T40419342416-30-2
    IRES-C11 is a specific inhibitor of translation that targets the internal ribosome entry site (IRES) of the c-MYC gene. It functions by blocking the interaction between heterogeneous nuclear ribonucleoprotein A1, a trans-acting factor required for c-MYC IRES activity, and its corresponding IRES. Notably, IRES-C11 does not inhibit the IRES activity of BAG-1, XIAP, and p53.
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      KSI-3716
      T117831151813-61-4
      KSI-3716 is an inhibitor of c-Myc.
      • $242
      5 days
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      sAJM589
      T168392089-82-9
      sAJM589 is a Myc inhibitor(IC50: 1.8 μM).
      • $82
      5 days
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      c-Myc inhibitor 11
      T79438
      c-Myc inhibitor 11 (Compound 67e), a c-MYC inhibitor (p EC 50: 6.4), demonstrates high clearance, moderate volume of distribution, and a short half-life in rat pharmacokinetic assays, making it suitable for cancer research [1].
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      c-Myc inhibitor 12
      T79439
      Compound 67h, also known as c-Myc inhibitor 12, is a potent inhibitor of c-Myc, exhibiting a pEC50 value of 6.4 [1].
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      MYC-RIBOTAC
      T78055
      MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered to a small molecule that recruits and activates RNase L1. This interaction promotes the degradation of MYC mRNA, subsequently reducing MYC protein levels and inducing apoptosis, thereby presenting potential applications in anticancer research [1].
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      WBC100
      T779392095780-08-6
      WBC100 (14-D-Valine-TPL) is a potent, selective, orally active c-Myc glue degrader targeting the ubiquitin E3 ligase CHIP-mediated 26S proteasome pathway, primarily used in research for c-Myc overexpressing tumors [1].
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      Moracin D
      TN458169120-07-6
      Moracin C and moracin D, new phytoalexins from diseased mulberry, are antifungal compounds. Moracin may be protective influence in tumor promotion, utilization of Moracin may open a new avenue in the treatment of tumerigenesis.
      • $2,190
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      SYHA1815
      T2001242760195-67-1
      SYHA1815, an orally active RET inhibitor (IC50=0.9 nmol L), demonstrates antitumor activity. It exhibits greater selectivity for RET over KDR (IC50=15.9 nmol L). SYHA1815 operates by downregulating c-Myc, arresting the G1 cell cycle, and inhibiting RET-driven cell proliferation.
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      10-14 weeks
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      Aaptamine
      TN135485547-22-4
      Aaptamine functions as a proteasome inhibitor, it activates p21 promoter in a p53-independent manner.
      • $550
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      Moracin T
      TN45821146113-27-0
      Moracin treatment can inhibit the double 12-O-tetradecanoylphorbol 13-acetate (TPA) treatment-induced morphological changes reflecting inflammatory response, including leucocyte infiltration, hyperplasia and cell proliferation; moracin treatment furthermo
      • $870
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      m-Se3
      T798722829939-44-6
      m-Se3 is a potent, selective inhibitor of c-MYC transcription with demonstrated capability to inhibit tumor growth and exhibit anti-cancer activity [1].
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      8-10 weeks
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      MDEG-541
      T78986
      MDEG-541 is a potent MYC-MAX degrader that exhibits antiproliferative activity by downregulating the expression of GSPT1, MYC, GSPT2, and PLK1 proteins [1].
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      Coronarin D
      TN3708119188-37-3
      Coronarin D shows promising antifungal activity against C. albicans in vitro, the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were 2 and 4 mg/mL, respectively; it is active against tested Gram-positive bacteria, i
      • $1,779
      7-10 days
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