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Astemizole

🥰Excellent
Catalog No. T1278Cas No. 68844-77-9
Alias Paralergin, Laridal, Histaminos

Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.

Astemizole

Astemizole

🥰Excellent
Purity: 99.67%
Catalog No. T1278Alias Paralergin, Laridal, HistaminosCas No. 68844-77-9
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$42In StockIn Stock
10 mg$58In StockIn Stock
25 mg$94In StockIn Stock
1 mL x 10 mM (in DMSO)$46In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.67%
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Product Introduction

Bioactivity
Description
Astemizole (Laridal) is a synthetic piperidinyl-benzimidazol derivative with antiallergic properties, acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria.
SynonymsParalergin, Laridal, Histaminos
Chemical Properties
Molecular Weight458.57
FormulaC28H31FN4O
Cas No.68844-77-9
SmilesC(N1C=2C(N=C1NC3CCN(CCC4=CC=C(OC)C=C4)CC3)=CC=CC2)C5=CC=C(F)C=C5
Relative Density.1.2 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (119.94 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (10.9 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1807 mL10.9035 mL21.8069 mL109.0346 mL
5 mM0.4361 mL2.1807 mL4.3614 mL21.8069 mL
10 mM0.2181 mL1.0903 mL2.1807 mL10.9035 mL
20 mM0.1090 mL0.5452 mL1.0903 mL5.4517 mL
50 mM0.0436 mL0.2181 mL0.4361 mL2.1807 mL
100 mM0.0218 mL0.1090 mL0.2181 mL1.0903 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

R-43512R43512R 43512PotassiumChannelPotassium ChannelKcsAInhibitorinhibitHistamineReceptorHistamine Receptorhistamine H1-receptorhERG K+H1 receptorAstemizoleantipruriticantihistamine drug
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