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ONT-093
🥰Excellent
Catalog No. T63338Cas No. 216227-54-2
Alias ONT093, OC144 093, OC 144-093, OC 144093
ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.
ONT-093
🥰Excellent
Purity: 98.86%
Catalog No. T63338Alias ONT093, OC144 093, OC 144-093, OC 144093Cas No. 216227-54-2
ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $41 | In Stock | In Stock | |
| 5 mg | $92 | In Stock | In Stock | |
| 10 mg | $133 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:98.86%
Appearance:Solid
Color:Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | ONT-093 (OC-144-093) is an oral P-glycoprotein (P-gp) inhibitor with potential anti-cancer activity, used in the study of myelodysplastic syndromes. |
| Targets&IC50 | P-gp:0.032 μM (EC50) |
| In vitro | ONT-093 is an orally active, potent, and non-toxic P-GP-mediated multidrug resistance inhibitor. ONT-093 reversed multidrug resistance (MDR) to doxorubicin, paclitaxel, and vinblastine in human lymphoma, breast, ovarian, uterine, and colorectal cancer cell lines expressing P-glycoprotein (P-gp), with a mean EC50 of 0.032 μM. ONT-093 blocked the binding of [3H] azzapine to P-glycoprotein and inhibited P-glycoprotein ATPase activity. [1] |
| In vivo | ONT-093 extended the lifespan of doxorubicin-treated mice implanted with MDR P388 leukemia cells by >100% and significantly enhanced the in vivo anti-tumor activity of paclitaxel in MDR human breast and colon cancer xenotransplantation models. [1] |
| Synonyms | ONT093, OC144 093, OC 144-093, OC 144093 |
| Molecular Weight | 494.67 |
| Formula | C32H38N4O |
| Cas No. | 216227-54-2 |
| Smiles | N(C(C)C)C1=CC=C(C2=C(N=C(N2)C3=CC=C(/C=C/COCC)C=C3)C4=CC=C(NC(C)C)C=C4)C=C1 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Methanol: 100 mg/mL (202.15 mM), Sonication is recommended. DMSO: 80 mg/mL (161.72 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Methanol
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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